In the title compound, [Au(C(10)H(11)N(2)O(3)S)(C(18)H(33)P)], the gold(I) atom is linearly coordinated within a SP donor set. The distortion from linearity [S-Au-P = 177.54 (3)°] can be traced to an intra-molecular Au⋯O contact of 3.009 (3) Å. In the crystal, layers of mol-ecules are stabilized by a combination of C-H⋯O and C-H⋯π inter-actions.
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http://dx.doi.org/10.1107/S1600536809042767 | DOI Listing |
Acta Med Philipp
December 2024
Department of Pharmacology and Toxicology, College of Medicine, University of the Philippines Manila, Manila, Philippines.
Background And Objective: Scabies is the second most common cause of disability due to skin disease in the Philippines. However, there were no cited studies in Global Burden of Disease 2019 and the disability-adjusted life years (DALY) computations were most likely based on statistical modelling. The Philippine Department of Health has embarked on a program to estimate the disease burden of priority diseases in the country, which include scabies.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.
The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide synthesis pathway for clinical use are currently unavailable. We synthesized a safe and orally bioavailable inhibitor, termed ALT-007, targeting the rate-limiting enzyme of ceramide synthesis, serine palmitoyltransferase (SPT).
View Article and Find Full Text PDFPEC Innov
June 2025
Department of Respiratory Medicine, Royal Devon and Exeter Hospital, University of Exeter, Exeter, United Kingdom.
Objective: To assess the feasibility and acceptability of adapting a psychoeducation course (Body Reprogramming) for severe asthma and finding suggestions for improvement.
Methods: Severe asthma patients were recruited from a single centre and enrolled in an online group-based course. Each course consisted of four sessions: introduction to BR, stress, exercise, and diet.
J Orthop
July 2025
Department of Orthopaedic Surgery, Virginia Commonwealth University, 1250 E. Marshall Street, Richmond, VA, 23219, USA.
Background: The use of large multi-institutional databases in rotator cuff repair (RCR) research is expanding, but these studies are observational and cannot establish causation. This study examines the prevalence of causal language in clinical RCR database studies published from 2013 to 2022.
Methods: Administrative database and clinical registry studies on RCR published in eight orthopaedic journals from 2013 to 2022 were systematically identified and graded by two reviewers for the presence, absence, or inconsistent use of causal language in both the title/abstract and the full text.
Heliyon
January 2025
Department of Orthopedics, Beijing LongFu Hospital, Beijing, China.
Objective: We aimed to investigate the effects of Tongluo Zhitong formula on synovial fibroblast proliferation in human knee osteoarthritis (KOA).
Methods: Discarded synovial tissue collected from patients undergoing total knee arthroplasty at our hospital was digested with type I collagenase. Primary culture was performed on three to four generations of fibroblasts, which were treated with high, medium, and low concentrations of Tongluo Zhitong formula.
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