The crystal structure of the title compound, C(11)H(7)BrN(2)O(6), establishes the substitution positions of the nitro groups from the nitration reaction of 7-methyl-4-bromo-methyl coumarin. The mean planes of the nitro groups form dihedral angles of 43.9 (8) and 52.7 (10)° with the essentially planar [maximum deviation 0.031 (6) Å] benzopyran ring system.
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http://dx.doi.org/10.1107/S160053680903596X | DOI Listing |
Pharmaceutics
November 2024
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Nitazoxanide (NTX) exhibits promising therapeutic potential; its effectiveness is constrained by its low oral bioavailability due to its poor water solubility and limited permeability. This study focused on developing a complex of NTX with β-cyclodextrins (β-CDs), specifically β-CD and hydroxypropyl-β-cyclodextrin (Hβ-CD), to enhance the solubility and antiviral activity of NTX. The formation of the β-CD:NTX in an aqueous solution was verified using UV-visible spectroscopy, confirming a 1:1 inclusion complex.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department for Cardiovascular Physiology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Subotića 4, P.O. Box 39, 11129 Belgrade, Serbia.
Previously, we confirmed systemic antihypertensive and antioxidant properties of L. leaf extract (UE) in spontaneously hypertensive rats (SHR). Here, we aimed to evaluate whether UE can alter the NO and Nrf-2 signaling to prevent local oxidative stress and kidney damage in the model of essential hypertension.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang, Henan 471023, People's Republic of China.
The sensitive and selective identification of nitroaromatic explosives and industrially ubiquitous nitrates, which are harmful to the environment, is crucial from the viewpoints of security and environmental remediation. New multifunctional fluorescent porous materials that can sense nitro-explosives and nitrates are under continuous development. To this end, this study synthesizes 3,10,15-/-3,10,16-tribromotrinaphtho[3.
View Article and Find Full Text PDFAddressing the pressing need to develop affordable and efficient catalysts is essential. In this study, we successfully synthesized CuBiS nanostructures with a modified morphology using three different nitrogen bases: DBN, DBU, and DABCO a hydrothermal technique. These nanostructures were used for the electrochemical detection of organic nitro groups, a previously unexplored application for this material.
View Article and Find Full Text PDFRSC Adv
January 2025
V. Ye. Lashkaryov Institute of Semiconductor Physics, National Academy of Sciences of Ukraine 41 Nauky Avenue 03028 Kyiv Ukraine
Detecting small concentrations of nitro-compounds surface-enhanced Raman spectroscopy (SERS) is reported. In particular, explosive analogues, such as 4-nitrophenol, 1-nitronaphthalene, and 5-nitroisoquinoline, and an explosive material (picric acid) are investigated and prepared by measurements using two different methods. One method involved mixing the analyte with plasmonic silver nanoparticles (Ag NPs) in a solution, followed by subsequent drop-casting of the mixture onto a silicon substrate.
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