In the title compound, C(11)H(17)ClNO(+)·Cl(-), the side chain of the ethyl-amine group is orientated approximately perpendicular to the benzene ring, the dihedral angle between the C/C/N plane of the ethyl-amine group and the benzene plane being 83.5 (3)°. In the crystal structure, inter-molecular O-H⋯Cl and N-H⋯Cl hydrogen bonds are observed. The crystal studied was an inversion twin with a 0.51 (10):0.49 (10) domain ratio.
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http://dx.doi.org/10.1107/S1600536809031146 | DOI Listing |
IUCrdata
October 2024
Department of Chemistry, National College, Tiruchirappalli, Tamil Nadu, India.
In the crystal of the title compound, CHN, the mol-ecules are linked by N-H⋯N hydrogen bonds, generating a (4) chain extending along the -axis direction. One of the ethyl groups is disordered over two sets of sites with a refined occupancy ratio of 0.582 (15):0.
View Article and Find Full Text PDFPsychopharmacology (Berl)
December 2024
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Rationale: G-protein biased mu-opioid receptor (MOR) agonists have been reported to exhibit superior therapeutic windows compared to prototypical MOR agonists when relating antinociception to respiratory depression. However, there is relatively little research on the abuse potential of G-protein biased MOR agonists in relation to other behavioral endpoints.
Objectives: The aim of the present study was to quantitatively compare the reinforcing, antinociceptive, and respiratory-depressant effects of the prototypical MOR agonists, fentanyl and oxycodone, to the G-protein biased MOR agonists, SR14968 and SR17018, in male and female rats.
IUCrdata
July 2024
Lab. Síntesis de Complejos, Fac. Cs. Quím.-BUAP, Ciudad Universitaria, PO Box, 72592 Puebla, Mexico.
The Pd complex bis-{()-(-)--[(biphenyl-2-yl)methyl-idene]1-(4-meth-oxy-phen-yl)ethanamine-κ}di-chlorido-palladium(II), [PdCl(CHNO)], crystallizes in the monoclinic Sohncke space group 2 with a single mol-ecule in the asymmetric unit. The coordination environment around the palladium is slightly distorted square planar. The N-Pd-Cl bond angles are 91.
View Article and Find Full Text PDFDrug Des Devel Ther
July 2024
Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Background: Oliceridine is a novel G protein-biased ligand μ-opioid receptor agonist. This study aimed to assess the pharmacokinetics and safety profile of single-ascending doses of oliceridine fumarate injection in Chinese patients with chronic non-cancer pain.
Methods: Conducted as a single-center, open-label trial, this study administered single doses of 0.
Acta Crystallogr E Crystallogr Commun
March 2024
Department of Chemistry, Ramakrishna Mission Vivekananda Centenary College, Rahara, Kolkata-700118, West Bengal, India.
The title compound, (CHN)[V(CHNO)O]·HO, was synthesized aerial oxidation on refluxing picolinohydrazide with ethyl picolinate followed by addition of VO(acac) and di-ethyl-amine in methanol. It crystallizes in the triclinic crystal system in space group . In the complex anion, the dioxidovanadium(V) moiety exhibits a distorted square-pyramidal geometry.
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