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Safety profile of miltefosine in the treatment of cutaneous leishmaniasis.
PLoS One
December 2024
Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Cutaneous leishmaniasis (CL) is a neglected tropical disease that poses a significant public health challenge in Brazil and worldwide. Miltefosine, the only orally administered drug available for CL, was recently incorporated into Brazil's treatment protocols following recommendations by the World Health Organization (WHO) and revisions by national health authorities. While this represents an important advancement, miltefosine is associated with frequent gastrointestinal side effects and potential teratogenic risks, necessitating careful patient eligibility assessments and close clinical monitoring throughout treatment.
View Article and Find Full Text PDF: A Tale of Stealth and Endurance.
ACS Infect Dis
December 2024
BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad 500039, India.
() , an opportunistic human fungal pathogen, causes mucosal and deep-seated infections in immunocompromised individuals. Recently designated as a high-priority fungal pathogen by the World Health Organization (WHO), exhibits low inherent susceptibility to azole antifungals. In addition, about 10% clinical isolates of display co-resistance to both azole and echinocandin drugs.
View Article and Find Full Text PDFDevelopment of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery.
Daru
December 2024
Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia.
Background: Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vagina and vulva. Nevertheless, the substance's limited capacity to dissolve in water leads to poor absorption when taken orally, hence diminishing its therapeutic efficacy. In order to address this limitation, β-cyclodextrin (βCD) was used to create AMB in the form of an inclusion complex.
View Article and Find Full Text PDFEfficacy and Safety of Fluconazole Mucoadhesive Patches in Human Immunodeficiency Virus-Related Oral Candidiasis.
J Int Assoc Provid AIDS Care
December 2024
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
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Efficacy of palifermin in the treatment of oral mucositis in non-hematopoietic stem cell transplant pediatric patients: experience of a single tertiary hospital.
J Egypt Natl Canc Inst
December 2024
Department of Pediatric Hematology/Oncology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Background: Severe oral mucositis (OM) is one of the adverse events post-chemotherapy, radiation, and stem cell transplantation with major clinical and economic impact. The management of severe OM remains challenging. This study aimed to look for the benefit and clinical impact of palifermin for mucositis among the non-transplanted pediatric cancer population.
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