AI Article Synopsis
- PVCs were studied in an animal model to determine if they can cause cardiomyopathy, with an emphasis on their reversibility.
- Thirteen dogs were divided into two groups: one receiving bigeminal PVCs for 12 weeks and a control group. Results showed significant cardiomyopathy only in the PVC group, as indicated by reduced heart function and increased left ventricular size.
- The study concluded that PVC-induced cardiomyopathy can occur in structurally normal hearts and is reversible after stopping PVCs, without the typical tissue damage seen in other cardiomyopathy models.
Article Abstract
Background: Premature ventricular contractions (PVCs) commonly coexist with cardiomyopathy. Recently, PVCs have been identified as a possible cause of cardiomyopathy. We developed a PVC-induced cardiomyopathy animal model using a novel premature pacing algorithm to assess timeframe and reversibility of this cardiomyopathy and examine the associated histopathologic abnormalities.
Methods And Results: Thirteen mongrel dogs were implanted with a specially programmed pacemaker capable of simulating ventricular extrasystoles. Animals were randomly assigned to either 12 weeks of bigeminal PVCs (n = 7) or no PVCs (control, n = 6). Continuous 24-hour Holter monitoring corroborated ventricular bigeminy in the PVC group (PVC, 49.8% versus control, < 0.01%; P<0.0001). After 12 weeks, only the PVC group had cardiomyopathy, with a significant reduction in left ventricular ejection fraction (PVC, 39.7 ± 5.4% versus control, 60.7 ± 3.8%; P < 0.0001) and an increase in left ventricular end-systolic dimension (PVC, 33.3 ± 3.5 mm versus control, 23.7 ± 3.6 mm; P < 0.001). Ventricular effective refractory period showed a trend to prolong in the PVC group. PVC-induced cardiomyopathy was resolved within 2 to 4 weeks after discontinuation of PVCs. No inflammation, fibrosis, or changes in apoptosis and mitochondrial oxidative phosphorylation were observed with PVC-induced cardiomyopathy.
Conclusions: This novel PVC animal model demonstrates that frequent PVCs alone can induce a reversible form of cardiomyopathy in otherwise structurally normal hearts. PVC-induced cardiomyopathy lacks gross histopathologic and mitochondrial abnormalities seen in other canine models of cardiomyopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175603 | PMC |
| http://dx.doi.org/10.1161/CIRCEP.111.962381 | DOI Listing |
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