AI Article Synopsis

  • - This study investigates how different neonicotinoid compounds, which contain an N-haloacetylimino group, relate to their insect-killing effectiveness.
  • - Researchers found several promising candidate compounds that display strong insecticidal properties and their molecular interactions with insect nicotinic receptors.
  • - The halogen atoms (like fluorine, chlorine, bromine, and iodine) in these compounds interact with specific parts of the receptor through hydrogen bonding and hydrophobic interactions, contributing to their effectiveness.

Article Abstract

This structure-activity relationship study for neonicotinoids with an N-haloacetylimino pharmacophore identifies several candidate compounds showing outstanding insecticidal potency and consequently leads to establishing their molecular recognition at an insect nicotinic receptor structural model, wherein the neonicotinoid halogen atoms (fluorine, chlorine, bromine, and iodine) variously interact with the receptor loops C-D interfacial niche via H-bonding and/or hydrophobic interactions.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2011.04.107DOI Listing

Publication Analysis

Top Keywords

molecular recognition
8
recognition insect
8
insect nicotinic
8
nicotinic receptor
8
n-haloacetylimino neonicotinoids
4
neonicotinoids potency
4
potency molecular
4
receptor structure-activity
4
structure-activity relationship
4
relationship study
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!