This study has demonstrated that the treatment of patients with grade II-III arterial hypertension using fixed combinations of corinetec and gyzaar supplemented by acupuncture reflexotherapy resulted in a significantly more pronounced decrease of daily monitored arterial pressure than in patients who received the drug therapy without acupuncture.
Download full-text PDF |
Source |
---|
J Physiol
January 2025
Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Animal Model Exp Med
January 2025
Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, China.
Background: To investigate the toxicity of N-n-butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes.
Methods: The acute median lethal dose (LD) of F2 was determined using the Bliss method following intravenous administration in mice. Routine surface electrocardiograms (ECGs) and arterial blood pressures (aBPs) were recorded under general anesthesia in untreated and pharmacologically vagotomized mice injected with F2.
Cardiopulmonary bypass (CPB) in cardiac surgery is associated with a high risk of postoperative neurological complications. Perioperative use of vasopressors is common to counteract arterial hypotension in this setting. However, use of α-agonist vasopressors has been associated with cerebral desaturations.
View Article and Find Full Text PDFJ Pers Med
December 2024
Medicine School, Pontifical Catholic University of Goiás, Goiânia 74605-010, Brazil.
Systemic arterial hypertension contributes to cardiovascular morbidity and mortality worldwide. Many patients cannot achieve optimal blood pressure (BP) control with traditional therapies, which often results in poor patient adherence and limited long-term efficacy. We investigated the potential of RNA interference (RNAi) therapies targeting hepatic angiotensinogen (AGT) for hypertension management.
View Article and Find Full Text PDFCurr Drug Metab
January 2025
Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Deverakeggahalli, Kanakapura Road, Ramanagara Distt, Karnataka, 562112, India.
Background: Hypertension, which affects 1.28 billion people globally aged 30 to 79, is characterized by continuously high blood pressure (140/90 or more) and raises the risk of premature death. Losartan, an angiotensin receptor blocker (ARB), is suggested for patients under the age of 55 who cannot take ACE inhibitors as a first treatment option.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!