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Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.
Neurourol Urodyn
February 2024
Experimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, Porto, Portugal.
Article Synopsis
- Interstitial cystitis/bladder pain syndrome (IC/BPS) is a painful condition that affects the bladder and is linked to an overactive response in the body.
- Scientists studied how a model of stress in mice (maternal deprivation model) can create pain similar to IC/BPS, focusing on two special receptors (A1AAR and TRPV1) that help control pain and bladder function.
- The study found that the pain behavior was mainly seen in female mice, and blocking the receptors helped reduce pain and bladder problems, suggesting that targeting these receptors could help treat people with IC/BPS.
Calciphylaxis, beware the ophthalmic mimic: A case series.
Clin Nephrol Case Stud
December 2023
Department of Ophthalmology, and.
Article Synopsis
- This text discusses two rare cases of calciphylaxis that showed eye-related issues without typical skin symptoms, aiming to increase awareness of the condition.
- The cases include a 76-year-old woman with kidney failure and anterior ischemic optic neuropathy (AION), and a 44-year-old man on dialysis with AION and central retinal artery occlusion (CRAO).
- It emphasizes the importance of recognizing calciphylaxis in kidney patients with eye problems, and suggests a temporal artery biopsy for accurate diagnosis to prevent unnecessary treatments like steroids.
Hyperexcitability of muscle spindle afferents in jaw-closing muscles in experimental myalgia: Evidence for large primary afferents involvement in chronic pain.
Exp Physiol
January 2024
Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada.
The goals of this review are to improve understanding of the aetiology of chronic muscle pain and identify new targets for treatments. Muscle pain is usually associated with trigger points in syndromes such as fibromyalgia and myofascial syndrome, and with small spots associated with spontaneous electrical activity that seems to emanate from fibers inside muscle spindles in EMG studies. These observations, added to the reports that large-diameter primary afferents, such as those innervating muscle spindles, become hyperexcitable and develop spontaneous ectopic firing in conditions leading to neuropathic pain, suggest that changes in excitability of these afferents might make an important contribution to the development of pathological pain.
View Article and Find Full Text PDFRevisiting a classical theory of sensory specificity: assessing consistency and stability of thermosensitive spots.
J Neurophysiol
December 2023
Institute of Cognitive Neuroscience, University College London, London, United Kingdom.
Thermal sensitivity is not uniform across the skin, and is particularly high in small (∼1 mm) regions termed "thermosensitive spots." These spots are thought to reflect the anatomical location of specialized thermosensitive nerve endings from single primary afferents. Thermosensitive spots provide foundational support for "labeled line" or specificity theory of sensory perception, which states that different sensory qualities are transmitted by separate and specific neural pathways.
View Article and Find Full Text PDFPurtscher's Retinopathy After Cardiopulmonary Resuscitation: A Literature Review.
Cureus
April 2023
Department of Ophthalmology, Faculty of Medicine, University of Malaya Eye Research Centre, Universiti Malaya, Kuala Lumpur, MYS.
Purtscher's retinopathy is a rare angiopathy reported in patients with a history of severe trauma and other systemic diseases. The diagnosis is made on clinical grounds, and the severity varies. A 41-year-old gentleman with underlying poorly controlled diabetes mellitus and dyslipidemia was referred to the ophthalmology department for diabetic retinopathy screening.
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