Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC362284 | PMC |
| http://dx.doi.org/10.1128/mcb.10.4.1773-1778.1990 | DOI Listing |
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