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Primary tracheal hyalinizing clear cell carcinoma with EWSR1 rearrangement: A case report.
Oncol Lett
March 2025
Department of Thoracic Surgery, Tianjin Chest Hospital Affiliated to Tianjin University, Tianjin 300222, P.R. China.
Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade epithelial tumor predominantly found in the salivary glands, with tracheal involvement being particularly uncommon. The present study details a case of primary tracheal HCCC and its clinical presentation, diagnostic challenges and the therapeutic approach used. A 34-year-old female patient presented with a 1-month history of intermittent dyspnea.
View Article and Find Full Text PDFPyDNA-templated AgNPs coupled with poly (β‑cyclodextrin) enhanced fluorescence: A facile platform for signal amplification detection of biothiols in living cells and zebrafish.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, PR China.
Accurate and sensitive fluorescence imaging of biothiols is essential for understanding the mechanism underlying some physiological and pathological events, as well as the prevention and diagnosis of diseases. However, low signal transduction efficiency and poor biocompatibility of fluorescence tags associated with current sensors hinder their potential utilizations. Herein, a smart biothiols sensitive vivo imaging platform on the basis of amplifying nanoprobe has been designed.
View Article and Find Full Text PDFKeratinocyte exosomal LOC285194 ameliorates psoriasis by inhibiting the differentiation of CD4T cells to Th17 cells through regulating miR-211-5p/SIRT1 axis.
IUBMB Life
January 2025
Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, People's Republic of China.
Keratinocytes exosome participates in the pathogenesis of psoriasis and exosomes always carry long non-coding RNAs (lncRNAs) into target cells to function as an essential immune regulator in psoriasis-related diseases. LncRNA LOC285194 is closely associated with the occurrence of psoriasis. However, whether keratinocyte exosomal LOC285194 participates in the process of psoriasis remains vague.
View Article and Find Full Text PDFCoexistence of a novel , double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review.
Front Oncol
December 2024
Department of Pathology, China-Janpan Friendship Hospital, Beijing, China.
Background: Anaplastic lymphoma kinase () rearrangement, the most common oncogenic rearrangement in lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients. gene is the most common partner of rearrangement, and distinct EML4-ALK fusions differ in their responsiveness to ALK tyrosine kinase inhibitors. However, the concurrence of two rearrangements in one patient and whose response to ALK-TKIs have rarely been reported so far.
View Article and Find Full Text PDFDisseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients.
J Natl Cancer Cent
December 2024
Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Background: Small cell lung cancer (SCLC) is a highly aggressive disease characterized by early metastasis. Aneuploid CD31 disseminated tumor cells (DTCs) and CD31 disseminated tumor endothelial cells (DTECs) residing in the bone marrow are generally considered as the initiators of metastatic process. However, the clinical significance of DTCs and DTECs in SCLC remains poorly understood.
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