AI Article Synopsis
- Swine-origin H1N1 influenza virus (S-OIV) emerged in 2009, affecting children more frequently, with fever as the primary symptom but also severe cases like pneumonia and encephalitis.
- A study compared T cells, B cells, and regulatory T cells in 5 affected children (with complications and without), 5 kids with seasonal influenza, and 5 healthy controls, revealing distinct immune responses in infected children.
- The results indicated that children with complications had an imbalance in immune responses, showing high levels of certain T cells and low levels of regulatory T cells, suggesting a failure to properly regulate the body's defense against the virus.
Article Abstract
Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet(+) CD4(+)CD8(+) T cells, monocytes, and B cells, granzyme B(+) and perforin(+) CD4(+), and CD8(+) T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4(+)CD25(+)Foxp3(+) regulatory T cells. In infected children with complications we observed high percentages of perforin(+) and interferon-γ(+) CD4(+) and CD8(+) T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
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| http://dx.doi.org/10.1016/j.humimm.2011.04.006 | DOI Listing |
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