Problem: While observational before-after studies are considered the industry standard for developing crash modification factors (CMFs), there are practical limitations that may preclude their use in highway safety analysis. There is a need to explore alternative methods for estimating CMFs.
Method: This paper employs case-control and cross-sectional analyses to estimate CMFs for fixed roadway lighting and the allocation of lane and shoulder widths.
Results: Based on the case-control method, the CMF for intersection lighting is 0.886, while the cross-sectional study indicates a CMF of 0.881. The CMFs developed for lane and shoulder widths are also similar when comparing the two methods.
Conclusions: This paper suggests that case-control and cross-sectional studies produce consistent results if care is taken in the study design and model development.
Impact On Industry: Case-control and cross-sectional studies may provide a viable alternative to estimate CMFs when a before-after study is impractical due to data restrictions.
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http://dx.doi.org/10.1016/j.jsr.2011.03.003 | DOI Listing |
Am J Hum Biol
January 2025
Department of Anthropology, The Pennsylvania State University, University Park, Pennsylvania, USA.
Objectives: The Developmental Origins of Health and Disease (DOHaD) framework contends that chronic diseases are attributable to behavioral and environmental risks encountered during vital periods of fetal and childhood development. Clinical research investigating irritable bowel syndrome (IBS) largely focuses on adult risk factors, with emerging evidence of epigenetic contributions. Limited work considers potential childhood exposures.
View Article and Find Full Text PDFFront Nutr
December 2024
Clinical Epidemiology Research Office, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Aims: To explore the effect of plasma homocysteine (Hcy) on cardiometabolic multimorbidity (CMM) among Chinses adults.
Methods: This study combined a community-based cross-sectional study with a 1:1 matched case-control study using propensity score method among adults aged over 30 years in six districts randomly selected from Hunan Province, China. We recruited 5,258 people, of whom 4,012 met the study criteria were enrolled.
Sci Rep
January 2025
Department of Colorectal Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315000, China.
Recent studies suggest the role of gut microbes in bile acid metabolism in the development and progression of colorectal cancer. However, the surveys of the association between fecal bile acid concentrations and colorectal cancer (CRC) have been inconsistent. We searched online to identify relevant cross-sectional and case-control studies published online in the major English language databases (Medline, Embase, Web of Science, AMED, and CINAHL) up to January 1, 2024.
View Article and Find Full Text PDFRheumatol Int
January 2025
Department of Rheumatology and Immunology, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, 30-688, Poland.
Growing evidence suggests that serotonin is an important mediator in the cross-talk between immune and bone cells, playing a role in the pathogenesis of various types of inflammatory arthritis (IA). However, the relationship between circulating serotonin and different outcomes in three most prevalent IA - rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA), remains limited and requires further investigation. This study was performed to evaluate variations in serotonin serum levels among RA, PsA, and axSpA and to explore the utility of this biochemical marker in the assessment of disease activity and health status measurements provided by the Multi-Dimensional Health Assessment Questionnaire (MDHAQ).
View Article and Find Full Text PDFActa Derm Venereol
January 2025
Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel.
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.
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