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Comparison of 2.6- and 1.4-mm imaging probes for confocal laser endomicroscopy of the urinary tract. | LitMetric

AI Article Synopsis

  • Probe-based confocal laser endomicroscopy (pCLE) is a new imaging technology that enables high-resolution in vivo visualization of the urinary tract, using two different probe sizes for comparison.
  • A study involving 67 patients showed that the 2.6-mm probe offered superior image resolution, while the 1.4-mm probe provided a wider field view and better access to hard-to-reach areas in the bladder.
  • The findings suggest that although the 2.6-mm probe is better for detailed cellular imaging, further improvements to the 1.4-mm probe's resolution and diagnostic accuracy are necessary for broader use in urinary tract assessments.

Article Abstract

Introduction: Probe-based confocal laser endomicroscopy (pCLE) is an emerging technology for dynamic, in vivo imaging of the urinary tract with micron-scale resolution. We conducted a comparative analysis of pCLE with a 2.6-mm probe and a 1.4-mm probe that is compatible with flexible endoscopes.

Materials And Methods: Sixty-seven patients scheduled for bladder tumor resection were recruited. pCLE imaging was performed using 2.6- and 1.4-mm probes. Image quality with the different probes was examined and further compared with standard histopathology.

Results: Images with the 2.6-mm probe have better resolution of cell morphology. The 1.4-mm probe has a wider field of view and better view of microarchitecture. While image quality with the 2.6-mm probe is superior, the 1.4-mm probe is compatible with flexible cystoscopy and maneuverability is maintained, enabling imaging of areas of the bladder that were previously challenging to access with the larger probe.

Conclusions: The optical specifications of the 2.6-mm probe are more suitable for distinguishing urinary tract histopathology. Further design optimization to improve resolution and additional validation of the diagnostic accuracy of the smaller probe are needed to help extend application of pCLE for optical biopsy of the upper and lower urinary tract.

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Source
http://dx.doi.org/10.1089/end.2010.0686DOI Listing

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