We demonstrate single-shot readout of a silicon quantum dot spin qubit, and we measure the spin relaxation time T1. We show that the rate of spin loading can be tuned by an order of magnitude by changing the amplitude of a pulsed-gate voltage, and the fraction of spin-up electrons loaded can also be controlled. This tunability arises because electron spins can be loaded through an orbital excited state. Using a theory that includes excited states of the dot and energy-dependent tunneling, we find that a global fit to the loading rate and spin-up fraction is in good agreement with the data.
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http://dx.doi.org/10.1103/PhysRevLett.106.156804 | DOI Listing |
Many protein bioconjugation strategies focus on the modification of lysine residues owing to the nucleophilicity of their amine side-chain, the generally high abundance of lysine residues on a protein's surface and the ability to form robustly stable amide-based bioconjugates. However, the plethora of solvent accessible lysine residues, which often have similar reactivity, is a key inherent issue when searching for regioselectivity and/or controlled loading of an entity. A relevant example is the modification of antibodies and/or antibody fragments, whose conjugates offer potential for a wide variety of applications.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Exosomes are natural membrane-enclosed nanovesicles (30-150 nm) involved in cell-cell communication. Recently, they have garnered considerable interest as nanocarriers for the controlled transfer of therapeutic agents to cells. Here, exosomes were derived from bone marrow mesenchymal stem cells using three different isolation methods.
View Article and Find Full Text PDFClin Biomech (Bristol)
December 2024
BioMotion Center, Institute of Sports and Sports Science, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. Electronic address:
Background: Turning movements are frequently encountered during daily life and require more frontal and transverse hip mobility than straight walking. Thus, analysis of turning might be an insightful addition in the evaluation of conservative treatment approaches for hip osteoarthritis patients. The study objective was to quantify the effects of mild-to-moderate symptomatic hip osteoarthritis on lower-body turning biomechanics and evaluate the effects of hip bracing in this cohort.
View Article and Find Full Text PDFLangmuir
January 2025
Univ. Rouen Normandie, Normandie Univ., SMS, UR 3233, F-76000 Rouen, France.
It has been shown that depositing ketoprofen as thin films on glass substrates has a stabilizing effect on the amorphous state of ketoprofen. Polyethylene glycol ( = 6000 g/mol) was mixed with ketoprofen in a wide range of concentrations. Amorphous thin films were prepared by spin coating and subjected to storage conditions with different levels of relative humidity.
View Article and Find Full Text PDFSmall
December 2024
College of Material Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
Lithium-sulfur batteries (LSBs) face challenges from the shuttle effect of lithium polysulfides (LiPSs) and slow redox kinetics. In this study, a NiCo-Doped 3D Ordered Mesoporous Carbon (NiCo-3DOMC) composite material is synthesized using a gel-crystalline template and sol-gel method to modify polypropylene separators in LSBs. Density Functional Theory calculations and experiment results demonstrate that under a magnetic field, the NiCo-3DOMC enhances adsorption and catalyzes the conversion of LiPSs, effectively mitigating the shuttle effect and boosting redox kinetics.
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