Diabetes in the elderly is a growing public health problem, impacting both quality of life and autonomy. In the absence of prospective studies, the therapeutic goal will depend both on classical diabetes-related criteria and on geriatric assessment to determine the degree of frailty. The glycemic goal for elderly diabetic patients in good general health is roughly the same as for younger patients, while the target should be less strict for frail patients, in order to avoid both hypoglycemia and excessive treatment constraints that have no direct benefit. As elderly diabetic patients have more frequent severe degenerative disorders and other cardiovascular risk factors, the treatment goals must take into account not only diabetes itself but also the consequences of aging. This clinical assessment, which is crucial for individually tailored treatment, must be undertaken by a multidisciplinary team.
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Viruses
December 2024
1st Internal Medicine Department, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, 55436 Thessaloniki, Greece.
People with HIV (PWH) have an elevated risk of cardiovascular disease compared to those without HIV. This study aimed to investigate the relative serum expression of microRNAs (miRNAs) associated with arterial stiffness, a significant marker of cardiovascular disease. A total of 36 male PWH and 36 people without HIV, matched for age, body mass index, pack years, and dyslipidemia, were included in the study.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Internal Medicine, Kanai Hospital, 612-12, Yodokizu-cho, Fushimi-ku, Kyoto 613-0911, Japan.
Diabetes is known to reduce blood circulation in capillaries and arterioles; however, no devices can easily measure this on a daily basis. In this study, we developed a tool for measuring finger photoplethysmograms using green light and near-infrared LEDs. Thereafter, photoplethysmography was conducted on 25 inpatients/outpatients with diabetes and 21 adult males and females who had not been diagnosed with or treated for diabetes, hypertension, or cardiovascular disease (control group).
View Article and Find Full Text PDFPharmaceutics
November 2024
Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, No. 280 University Town Outer Ring East Road, Guangzhou 510006, China.
Background: Internal ocular diseases, such as macular edema, uveitis, and diabetic macular edema require precise delivery of therapeutic agents to specific regions within the eye. However, the eye's complex anatomical structure and physiological barriers present significant challenges to drug penetration and distribution. Traditional eye drops suffer from low bioavailability primarily due to rapid clearance mechanisms.
View Article and Find Full Text PDFToxics
December 2024
Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population.
Methods: To analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used.
Nutrients
December 2024
Facultad de Salud Pública y Nutrición (FaSPyN), Universidad Autónoma de Nuevo León (UANL), Monterrey 64460, Nuevo León, Mexico.
: The prevalence of metabolic syndrome in children has been increasing, raising concerns about early detection and clinical management. Adipokines, which are secreted by adipose tissue, play a critical role in metabolic regulation and inflammation, while gamma-glutamyl transferase (GGT), as a liver enzyme, is linked to oxidative stress and metabolic disorders. The objective was to examine the association of circulating adipokines and GGT with metabolic syndrome risk in school-aged children from Northeast Mexico.
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