AI Article Synopsis
- A 48-year-old male with Castleman disease exhibited symptoms of POEMS syndrome but initially showed no detectable M-protein through immunoelectrophoresis.
- He was diagnosed with POEMS syndrome after IgA-λ was found through immunofixation electrophoresis and a significantly high level of vascular endothelial growth factor (VEGF) was identified.
- Following diagnosis, the patient had a successful autologous peripheral blood stem cell transplantation and remained in good health without relapses for 15 months, highlighting the importance of immunofixation and VEGF levels in early diagnosis.
Article Abstract
A 48-year-old male with Castleman disease developed symptoms typical of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal-protein and skin changes) but M-protein was not detected by immunoelec-trophoresis. He was diagnosed as having POEMS syndrome based on IgA-λ detected by immunofixation electrophoresis and an increased level (3,170 pg/ml) of vascular endothelial growth factor (VEGF). After diagnosis, the patient underwent autologous peripheral blood stem cell transplantation safely and remained relapse-free and in good condition for 15 months. This case suggests that immunofixation electrophoresis and detection of elevated serum VEGF level are useful methods for earlier diagnosis of POEMS syndrome.
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