Objective: Our objective is to build a model that explains the association between the exposure to trace elements in the soil and the risk of neural tube defects.
Methods: We built a function with different parameters to describe the effects of trace elements on neural tube defects. The association between neural tube defects and trace element levels was transformed into an optimization problem using the maximum likelihood method.
Results: Tin, lead, nickel, iron, copper, and aluminum had typical layered effects (dosage effects) on the prevalence of neural tube defects. Arsenic, selenium, zinc, strontium, and vanadium had no effect, and molybdenum had one threshold value that affected the prevalence of birth defects.
Conclusion: As an exploratory research work, our model can be used to determine the direction of the effect of the trace element content of cultivated soil on the risk of neural tube defects, which shows the clues by the dosage effect of their toxicological characteristics. Based on our findings, future biogeochemical research should focus on the direct effects of trace elements on human health.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3967/0895-3988.2011.02.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Novel Variants of IGF2 Gene Are Linked With Neural Tube Defects-An In Silico to Clinical Approach in West Bengal, India.
Birth Defects Res
January 2025
Department of Zoology, University of Calcutta, Kolkata, India.
Background: Neural tube defects (NTDs) are defined as an incomplete closure of the neural tube (NT), with a prevalence of 1.2 per 1000 live births around the world. Methylation of the maternally imprinted gene Insulin-like growth factor 2 (IGF2) is one of the epigenetic mechanisms that contribute significantly to the development of NTDs.
View Article and Find Full Text PDFReassessing the Inclusion of Race in Prenatal Screening for Open Neural Tube Defects.
JAMA Pediatr
January 2025
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Total Intravenous Anesthesia for Intraoperative Neurophysiological Monitoring in a Child With Diastematomyelia: A Case Report.
Cureus
December 2024
Radiology, SRM Medical College Hospital and Research Center, Chennai, IND.
Intraoperative neurophysiological monitoring (IONM) has achieved popularity because it facilitates monitoring of the functional integrity of neural structures under general anesthesia. It aids in the early detection of injury and minimizes postoperative neurologic deficit or neurologic morbidity from surgical manipulations of various neurologic structures. The patient mentioned in this case report presented with lower limb radiculopathy and was diagnosed with diastematomyelia Type II, and she was planned for surgical intervention under general anesthesia.
View Article and Find Full Text PDFModerate levels of folic acid benefit outcomes for cilia based neural tube defects.
Dev Biol
January 2025
Department of Molecular, Cellular and Development Biology, University of Colorado, Boulder, CO 80309. Electronic address:
Folic acid (FA) supplementation is a potent tool to reduce devastating birth defects known as neural tube defects (NTDs). Though effective, questions remain how FA achieves its protective effect and which gene mutations are sensitive to folic acid levels. We explore the relationship between FA dosage and NTD rates using NTD mouse models.
View Article and Find Full Text PDFCryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1.
Nat Commun
January 2025
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations in Vangl are associated with developmental defects, including neural tube defects (NTDs), according to human cohort studies of sporadic and familial cases. The complex mechanisms underlying Vangl-mediated PCP signaling or Vangl-associated human congenital diseases have been hampered by the lack of molecular characterizations of Vangl.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!