AI Article Synopsis
- A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were created using a specific chemical reaction, and their behavior when dissolved in solution was analyzed using various microscopy and spectroscopy techniques.
- The PPO-PK copolymers showed a notable difference in pH behavior compared to previous poly(lysine) studies, which may be linked to changes in the hydrophobic properties of the PPO core.
- The study also explored how the unique properties of these copolymers could lead to self-assembly that responds to both pH and temperature, and assessed their potential for drug delivery through vesicle formation.
Article Abstract
A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were synthesized using Huisgen's 1,3-dipolar cycloaddition, and the solution self-assembly was studied using transmission electron microscopy, circular dichroism spectroscopy, and dynamic and static light scattering techniques. In contrast to previous studies of poly(lysine)-based block copolymers, PPO-PK exhibits a significant shift in the pH associated with the helix-coil transition of the poly(lysine) block, potentially a result of decreased hydrophobicity in the core PPO block. Given the proximity of the lower critical solution temperature of the PPO block, these materials exhibit both pH and temperature-responsive (i.e., "schizophrenic") self-assembly, the latter of which was interpreted in terms of changes in the second osmotic virial coefficient. Finally, the vesicle morphology obtained from these polymers was studied for the propensity in drug encapsulation and passive release.
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| http://dx.doi.org/10.1021/la200882f | DOI Listing |
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