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An Immunocytochemistry Method to Investigate the Translationally Active HIV Reservoir.
Int J Mol Sci
January 2025
MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
Despite the success of combination antiretroviral therapy (cART) to suppress HIV replication, HIV persists in a long-lived reservoir that can give rise to rebounding viremia upon cART cessation. The translationally active reservoir consists of HIV-infected cells that continue to produce viral proteins even in the presence of cART. These active reservoir cells are implicated in the resultant viremia upon cART cessation and likely contribute to chronic immune activation in people living with HIV (PLWH) on cART.
View Article and Find Full Text PDFMultifunctional Nanozyme with Aptamer-Based Ratiometric Fluorescent and Colorimetric Dual Detection of Prostate-Specific Antigen.
ACS Appl Mater Interfaces
January 2025
Key Laboratory for Special Functional Aggregate Materials of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
The adsorption of DNA probes onto nanomaterials represents a promising bioassay technique, generally employing fluorescence or catalytic activity to generate signals. A significant challenge is maintaining the catalytic activity of chromogenic catalysts during detection while enhancing accuracy by overcoming the limitations of single-signal transmission. This article presents an innovative multimodal analysis approach that synergistically combines the oxidase-like activity of Fe-N-C nanozyme (Fe-NC) with red fluorescent carbon quantum dots (R-CQDs), further advancing the dual-mode analysis method utilizing R-CQDs@Fe-NC.
View Article and Find Full Text PDFSelf-signaling colorimetric sensor for selective detection of dopamine based on CoFeO nanozyme accelerated dopamine polymerization.
Anal Chim Acta
February 2025
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, 730070, Lanzhou, Gansu, China. Electronic address:
Background: Reliable and selective detection of dopamine is crucial for the early diagnosis of various diseases. Transition metal based-nanozymes have shown great promise in the field of colorimetric detection of dopamine due to their remarkable stability and exceptional catalytic efficiency. However, these transition metal-based nanozymes typically function through a chromogenic reaction that relies on additional organic substrates, such as 3,3',5,5'-tetramethylbenzidine, to generate a detectable signal.
View Article and Find Full Text PDFImmobilization of a novel bacteriophage PpZDSS02 onto the peroxidase-mimicking Cu-MOF for colorimetric sensing of Proteus penneri encompassing both promotion and inhibition mechanisms.
Food Chem
January 2025
School of Food Science and Engineering, Yangzhou University, Yangzhou 225127, Jiangsu, China.
A chromogenic system utilizing a novel bacteriophage-integrated nanozyme was established for Proteus penneri detection. Initially, a novel bacteriophage PpZDSS02 was isolated and identified, demonstrating exceptional biological properties and harboring genes that exhibit specific recognition ability. Afterwards, a PpZDSS02-integrated Cu-MOF nanozyme (Cu-MOF@PpZDSS02) with peroxidase-mimicking activity was prepared, catalyzing 3, 3', 5, 5'-tetramethylbenzidine (TMB) chromogenic reaction.
View Article and Find Full Text PDFA Novel Screening System to Characterize and Engineer Quorum Quenching Lactonases.
Biotechnol Bioeng
January 2025
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, Minnesota, USA.
N-acyl l-homoserine lactones are signaling molecules used by numerous bacteria in quorum sensing. Some bacteria encode lactonases, which can inactivate these signals. Lactonases were reported to inhibit quorum sensing-dependent phenotypes, including virulence and biofilm.
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