Generations of disabled persons were inspired by the miraculous recovery Charles Fletcher Lummis made following a series of devastating strokes that began at the age of 28. The famed author, editor, and social activist was struck by misfortune again at 51 when he went bilaterally blind. At the height of his career, Lummis never let the loss of vision interfere with his many professional responsibilities or his personal life. The cause of Lummis's stroke and blindness has been the subject of speculation for nearly a century and involves one of the most sensitive and perplexing diagnoses in medicine.
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http://dx.doi.org/10.1001/archophthalmol.2011.79 | DOI Listing |
J Behav Ther Exp Psychiatry
December 2022
Boston University, Boston, MA, USA. Electronic address:
Hoarding disorder (HD) is a multifaceted problem that presents challenges both for understanding its dimensions and for developing effective treatments. We are grateful to have known Dr. Stanley J.
View Article and Find Full Text PDFAtten Percept Psychophys
June 2020
MIT Department of Brain & Cognitive Sciences, CSAIL, Cambridge, MA, 02139, USA.
Human beings subjectively experience a rich visual percept. However, when behavioral experiments probe the details of that percept, observers perform poorly, suggesting that vision is impoverished. What can explain this awareness puzzle? Is the rich percept a mere illusion? How does vision work as well as it does? This paper argues for two important pieces of the solution.
View Article and Find Full Text PDFMicroorganisms
December 2019
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
The study of the forces which govern the geographical distributions of life is known as biogeography, a subject which has fascinated zoologists, botanists and ecologists for centuries. Advances in our understanding of community ecology and biogeography-supported by rapid improvements in next generation sequencing technology-have now made it possible to identify and explain where and why life exists as it does, including within the microbial world. In this review, we highlight how a unified model of microbial biogeography, one which incorporates the classic ecological principles of selection, diversification, dispersion and ecological drift, can be used to explain community dynamics in the settings of both health and disease.
View Article and Find Full Text PDFBehav Brain Res
October 2018
Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence in Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
In this work, the effect of mild stress (elevated plus maze test, EPM) on the expression of endoplasmic reticulum (ER) stress markers in different brain areas of wild type (WT) and Wfs1-deficient (Wfs1KO) mice was investigated. The following ER stress markers were studied: activating transcription factor 6α (Atf6α), protein kinase-like ER kinase (Perk), X-box binding protein 1 (Xbp1) and its spliced form (Xbp1s), 78-kilodalton glucose regulated protein (Grp78), 94-kilodalton glucose regulated protein (Grp94), C/EBP homologous protein (Chop). Wfs1KO and WT mice, not exposed to EPM, had similar patterns of ER stress markers in the studied brain areas.
View Article and Find Full Text PDFArch Ophthalmol
May 2011
Department of Ophthalmology, University of South Florida, 12901 Bruce B. Downs Blvd, MDC Box 21, Tampa, FL 33612, USA.
Generations of disabled persons were inspired by the miraculous recovery Charles Fletcher Lummis made following a series of devastating strokes that began at the age of 28. The famed author, editor, and social activist was struck by misfortune again at 51 when he went bilaterally blind. At the height of his career, Lummis never let the loss of vision interfere with his many professional responsibilities or his personal life.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!