Five heat-labile, partially purified toxic products of Escherichia coli were distinguished by isoelectric focusing, molecular weight, and neutralization with homologous and heterologous antisera. Only two affected the morphology of Y-1 cells, induced fluid accumulation in rabbit ileal loops, and stimulated production of cyclic AMP in Vero cells; these two did not cross-neutralize and only one showed cross-neutralization with cholera antitoxin. The remaining three products were cytotoxic for Vero cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC422208 | PMC |
| http://dx.doi.org/10.1128/iai.22.3.644-648.1978 | DOI Listing |
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