Pretreatment of mice intraperitoneally with silica, trypan blue, or dextran sulfate to inhibit macrophage function markedly increased the lethality of a systemic intravenous infection with herpes simplex virus type 2, but did not affect the lethality or local virus growth after vaginal infection of mice with herpes simplex virus type 2. Agents which inhibit macrophage function by different mechanisms decreased host resistance to herpes simplex virus type 2, but the effects of macrophage-inhibitory agents may vary according to the route of virus infection.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC422201PMC
http://dx.doi.org/10.1128/iai.22.2.623-626.1978DOI Listing

Publication Analysis

Top Keywords

herpes simplex
16
simplex virus
16
virus type
16
macrophage-inhibitory agents
8
inhibit macrophage
8
macrophage function
8
virus
6
comparison macrophage-inhibitory
4
agents vaginal
4
vaginal systemic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!