Fate of chlortetracycline in Korean arable soil.

Bull Environ Contam Toxicol

National Veterinary Research & Quarantine Service (NVRQS), 620-2 Amnam-dong, Seo-gu, Busan, Republic of Korea.

Published: July 2011

The widespread use of the pharmaceutical chlortetracycline to treat human and animal infectious diseases is raising concern in Korea regarding the potential development of antibiotic-resistant bacteria. This study investigated the fate of chlortetracycline in Korean arable soils, to assess its environmental impact. The estimated half-life of chlortetracycline was 26.70-27.17 days indoors and 18.63-30.16 days outdoors. The chlortetracycline epimers and metabolites, 4-epichlortetracycline and 4-epi-anydrochlotetracycline were determined using liquid chromatography tandem mass spectroscopy. The respective concentrations of 4-epi-anydrochlotetracycline and 4-epichlortetracycline were 1.91%-9.71% and 11.12%-23.92% of the total chlortetracycline residual concentration indoors and 2.96%-11.44% and 17.61%-40.73% outdoors.

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http://dx.doi.org/10.1007/s00128-011-0298-8DOI Listing

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