Combining quantitative proteomics data processing workflows for greater sensitivity.

Nat Methods

Department of Medical Protein Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.

Published: June 2011

We here describe a normalization method to combine quantitative proteomics data. By merging the output of two popular quantification software packages, we obtained a 20% increase (on average) in the number of quantified human proteins without suffering from a loss of quality. Our integrative workflow is freely available through our user-friendly, open-source Rover software (http://compomics-rover.googlecode.com/).

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Source
http://dx.doi.org/10.1038/nmeth.1604DOI Listing

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