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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial.
Lancet Rheumatol
June 2024
Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, UK; National Institute for Health Research, Birmingham Biomedical Research Centre, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. Electronic address:
Background: The humoral and T-cell responses to booster COVID-19 vaccine types in multidisease immunocompromised individuals who do not generate adequate antibody responses to two COVID-19 vaccine doses, is not fully understood. The OCTAVE DUO trial aimed to determine the value of third vaccinations in a wide range of patients with primary and secondary immunodeficiencies.
Methods: OCTAVE-DUO was a prospective, open-label, multicentre, randomised, controlled, phase 3 trial investigating humoral and T-cell responses in patients who are immunocompromised following a third vaccine dose with BNT162b2 or mRNA-1273, and of NVX-CoV2373 for those with lymphoid malignancies.
Fragile Brilliance: The Troubled Lives of Herman Melville, Edgar Allan Poe, Emily Dickinson, and Other Great Authors.
J Psychiatr Pract
July 2023
TUCKER: Department of Psychiatry, Columbia College of Physicians & Surgeons, New York, NY.
[Pity as pain: Narrative Medicine and Melville's "Bartleby"].
Schmerz
April 2023
Institut for Kulturvidenskaber, Syddansk Universitet, Campusvej 55, 5230, Odense, Dänemark.
Background: Narrative Medicine is an interdisciplinary concept that joins literary texts and theory on the one hand with medical education on the other. It suggests that specific skills can be practiced by reflecting about literature and the arts, which represent existential human experiences. These skills are narrative competence, tolerance for ambiguity, changing one's perspective, empathy, and self-care.
View Article and Find Full Text PDFA highly virulent variant of HIV-1 circulating in the Netherlands.
Science
February 2022
Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.
View Article and Find Full Text PDFCetacean citations and the covenant of iron.
Notes Rec R Soc Lond
June 2019
Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge CB2 3RH, UK.
By the early decades of the nineteenth century, with surveys established as the weapon of choice for the fiscal military state, their instrumentation provided a focal point for radical attacks on political establishments. This paper considers a notorious dispute over mastery of iron in the instrumentation of magnetic surveying that took place in the 1830s between an Admiralty committee and the Reverend William Scoresby, a whaler-turned-clergyman. Scoresby staked his claim by drawing on the labour law of the whaleboats, a culture peculiarly preoccupied with the properties of bone and blubber, ink and skin, parchment and iron, where magnetism was forged in the 'combinations', as Scoresby put it, of such specific materials.
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