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Tenascin-X deficiency causing classical-like Ehlers Danlos syndrome type 1 in humans is a significant risk factor for GI and tracheal ruptures.
Clin Transl Gastroenterol
January 2025
Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Background: Classical-like Ehlers Danlos Syndrome type 1 (clEDS1) is a very rare form of Ehlers Danlos Syndrome (EDS) caused by tenascin-X (TNX) deficiency, with only 56 individuals reported. TNX is an extracellular matrix protein needed for collagen stability. Previous publications propose that individuals with clEDS1 might be at risk for gastrointestinal (GI) tract perforations and/or tracheal ruptures.
View Article and Find Full Text PDFEstablishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Langenbecks Arch Surg
January 2025
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality.
Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included.
Minimally Invasive Enucleation of Esophageal Leiomyoma: Experience From a Single Institution.
Cureus
October 2024
Digestive Surgery, Cho Ray Hospital, Ho Chi Minh City, VNM.
Introduction: Esophageal leiomyoma is a rare disease, most of which are benign, and endoscopic tumor removal surgery is a widely accepted treatment method. The two surgical approaches, laparoscopic and thoracoscopic, must be selected and applied according to the tumor size and location. The study aimed to evaluate the results, feasibility, and appropriate approach of minimally invasive surgery to treat esophageal leiomyoma.
View Article and Find Full Text PDFDescending necrotizing mediastinitis with esophageal perforation and tracheal ulcer: a case report and literature review.
Gen Thorac Cardiovasc Surg Cases
February 2024
Department of Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Background: Descending necrotizing mediastinitis (DNM) is a rare and life-threatening condition, with high morbidity and mortality. Consequently, appropriate and prompt diagnosis and treatment are necessary. Herein, we report a case of esophageal perforation and bronchial ulcer secondary to DNM, for which thoracoscopic esophagectomy was performed after the failure of conservative treatment.
View Article and Find Full Text PDFClosed laceration of the trachea, esophagus and guttural pouches in a mare caused by blunt trauma.
J Equine Vet Sci
December 2024
Faculty of Veterinary Science, University of Pretoria, M35, Onderstepoort, Pretoria 0110, South Africa.
Article Synopsis
- A mare was admitted with significant neck swelling, lethargy, and loss of appetite, leading to the discovery of serious injuries via radiography and endoscopy, including emphysema and lacerations.
- Treatment involved antimicrobials, fluids, and surgeries like temporary tracheostomy and esophagostomy, addressing issues such as deep cervical infection and esophageal impaction.
- After a recovery period with ongoing management, the mare successfully returned to competition after being discharged 51 days later.
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