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Maintenance therapy in NSCLC: why? To whom? Which agent? | LitMetric

AI Article Synopsis

  • Maintenance therapy is being explored as a new approach for treating advanced non-small cell lung cancer (NSCLC), with a focus on continuing or switching treatments after initial chemotherapy.
  • Initial trials showed that extending combination chemotherapy didn't improve survival but increased toxicity risks, leading to a need for different maintenance strategies.
  • The decision on which maintenance treatment to use is mostly based on individual circumstances since no comprehensive comparative trials have been conducted, highlighting the importance of personalized treatment plans.

Article Abstract

Maintenance therapy is emerging as a treatment strategy in the management of advanced non small cell lung cancer (NSCLC). Initial trials addressing the question of duration of combination chemotherapy failed to show any overall survival benefit for the prolonged administration over a fixed number of cycles with an increased risk for cumulative toxicity. Nowadays several agents with different ways of administration and a different pattern of toxicity have been formally investigated in the maintenance setting. Maintenance strategies include continuing with an agent already present in the induction regimen or switching to a different one. Taking into consideration that no comparative trials of maintenance with different chemotherapy drugs or targeted agents have been conducted, the choice and the duration of maintenance agents is largely empirical. Furthermore, it is still unknown and it remains an open question if this approach needs to be proposed to every patient in the case of partial/complete response or stable disease after the induction therapy. Here, we critically review available data on maintenance treatment, discussing the possibility to tailor the right treatment to the right patient, in an attempt to optimize costs and benefits of an ever-growing panel of different treatment options.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113744PMC
http://dx.doi.org/10.1186/1756-9966-30-50DOI Listing

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