With the accelerating human consumption of natural resources, the problems associated with endangered species caused by habitat loss and fragmentation have become greater and more urgent than ever. Conceptually associated with the theories of island biogeography, population viability analysis (PVA) has been one of the most important approaches in studying and protecting endangered species, and this methodology has occupied a central place in conservation biology and ecology in the past several decades. PVA has been widely used and proven effective in many cases, but its predictive ability and accuracy are still in question. Also, its application needs expand. To overcome some of the problems, we believe that PVA needs to incorporate some principles and methods from other fields, particularly landscape ecology and sustainability science. Integrating landscape pattern and socioeconomic factors into PVA will make the approach theoretically more comprehensive and practically more useful. Here, we reviewed the history, basic conception, research methods, and modeling applications and their accuracies of PVA, and proposed the perspective in this field.
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J Clin Lab Anal
January 2025
Clinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
Background: Low-temperature cryopreservation is a common method for scientific research and clinical sample preservation when utilizing flow cytometry. In flow cytometry data analysis, traditional manual "gating" is susceptible to past experience and faces the challenge of manual subjective bias, time-consuming, and multidimensional data analysis. With the development of algorithms, the advantages of dimensionality reduction and clustering in result analysis are gradually becoming more prominent.
View Article and Find Full Text PDFStacks (Portland)
November 2024
Vincent Wildlife Trust, Ledbury HR8 1EP, Herefordshire, UK.
The successful onset of recovery of the European pine marten () in some parts of Britain through range expansion and, more recently translocation for reintroductions, has resulted in a strong interest in reintroduction projects throughout the country. However, the geographic scope and conservation goals of these initiatives are often local and lack consideration of how they fit within the wider context of national-scale pine marten conservation. Here, we aim to maximize conservation benefit strategically at a national level by developing a simple, transparent, and transferable framework based on landscape modelling methods and spatially explicit population viability analyses.
View Article and Find Full Text PDFActa Trop
December 2024
Department of Entomology, Aggeu Magalhães Institute/Oswaldo Cruz Foundation (IAM/Fiocruz), Recife, Pernambuco, Brazil.
This study characterizes the Aedes aegypti population from Fernando de Noronha Island, Pernambuco, Brazil, prior to implementing the Sterile Insect Technique (SIT). The main objective was to assess changes in glutathione S-transferase (GST) enzyme activity, previously linked to cypermethrin resistance in this population, in 2010. GST activity was measured in both male and female mosquitoes, masse produced in lab, after exposure to ionizing radiation.
View Article and Find Full Text PDFCell Rep Med
December 2024
Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:
Studies indicate that breast tissue has a distinct modifiable microbiome population. We demonstrate that endocrine-targeting therapies, such as tamoxifen, reshape the non-cancerous breast microbiome to influence tissue metabolism and reduce tumorigenesis. Using 16S sequencing, we found that tamoxifen alters β-diversity and increases Firmicutes abundance, including Lactobacillus spp.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230006, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China. Electronic address:
Background: Glioblastoma (GBM) is the most aggressive tumor in the central nervous system. Tumor-associated macrophage (TAMs) represent a major immune cell population in tumor microenvironment (TME) and exert immunosuppressive effects that impede GBM treatment. Morusin is a flavonoid extracted from mulberry trees and has anti-tumor properties against various cancers, including glioma.
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