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The interplay of NAD and hypoxic stress and its relevance for ageing.
Ageing Res Rev
December 2024
Institute for Sports Medicine, Alpine Medicine and Health Tourism (ISAG), UMIT TIROL - Private University for Health Sciences and Health Technology, Hall in Tirol, Austria.
Nicotinamide adenine dinucleotide (NAD) is an essential regulator of cellular metabolism and redox processes. NAD levels and the dynamics of NAD metabolism change with increasing age but can be modulated via the diet or medication. Because NAD metabolism is complex and its regulation still insufficiently understood, achieving specific outcomes without perturbing delicate balances through targeted pharmacological interventions remains challenging.
View Article and Find Full Text PDFEuropean recommendations from health care professionals and people living with obesity on safe practice for bariatric and metabolic surgery medical tourism: a modified delphi consensus statement from EASO, IFSO-EC and ECPO.
Int J Surg
December 2024
School of Life Course & Population Sciences, Kings College London, UK.
Background: Bariatric and metabolic surgery tourism (BMT) is becoming an increasingly popular route to treatment for patients living with obesity. Recent reports have highlighted that some patients travelling abroad for bariatric surgery have received inadequate care, fraudulent care, and, tragically, some cases have resulted in death. This study aimed to define consensus in Europe regarding safe practices concerning BMT.
View Article and Find Full Text PDFCharacterization and evaluation of the adsorption of uremic toxins through the pyrolysis of pineapple leaves and peels and by forming a bio-complex with sodium alginate.
Int J Biol Macromol
December 2024
Department of Seafood Science, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. Electronic address:
Article Synopsis
- - The study investigates the optimal way to create activated carbon from pineapple waste (leaves and peels) through pyrolysis and its combination with sodium alginate to form a bio-complex.
- - Pyrolysis at 800 °C and activation with CO for 30 minutes resulted in high surface areas for the activated carbon, and while its microstructures showed some differences compared to commercial activated carbon, they had promising adsorption capabilities for uremic toxins.
- - The research highlights the potential for developing cost-effective adsorbent products from agricultural waste, aiming to effectively target uremic toxins in simulated gastrointestinal conditions, fitting into a circular economy perspective.
Experts' perspectives on human gene editing in Switzerland.
J Community Genet
December 2024
Health Ethics and Policy Lab, Health Sciences and Technologies Department ETH Zurich, Zurich, Switzerland.
Despite many specialized studies on the views of the public or stakeholders who face inherited conditions that may be treatable by HGE, limited studies have focused on experts' views towards Human Gene Editing (HGE). Therefore, in this study we conducted exploratory interviews with 14 experts (scientists, clinicians, social scientists, lawyers) in Switzerland to assess their views towards HGE and how they expect the Swiss public to view HGE. We found general acceptance of Somatic Gene Editing (SGE), but opinions towards Germline Gene Editing (GGE) were more divided.
View Article and Find Full Text PDFSevere interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model.
Ann Med
December 2025
Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5DM-ILD) often leads to acute respiratory failure and endangers lives. This study quantitatively analysed chest high-resolution computed tomography (HRCT) images to assess MDA5DM-ILD and establish a risk prediction model for severe ILD within six months.
Methods: We developed a 'Standardized Threshold Ratio Analysis & Distribution' (STRAD) to analyse lung HRCT images.
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