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Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis.
Nat Commun
November 2024
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Article Synopsis
- - Coordination compounds of lanthanides are crucial for biomedical uses like MRI contrast agents, but improvements in their stability and safety have been slow since the 1980s.
- - The introduction of ClickZip, a new synthetic strategy, significantly enhances the stability of these compounds, making them up to a million times more inert than previous methods, thus broadening their applications.
- - ClickZip chelates allow for efficient release and detection in biological samples, showing potential in advanced analysis techniques and specific applications in studying peptides related to cell penetration and obesity.
Triazole-Bridged Peptides with Enhanced Antimicrobial Activity and Potency against Pathogenic Bacteria.
ACS Infect Dis
August 2024
University of Cologne, Faculty of Mathematics and Natural Sciences, Department of Chemistry, Institute of Biochemistry, Zuelpicher Str. 47a, 50674 Cologne, Germany.
There are still no linear antimicrobial peptides (AMPs) available as a treatment option against bacterial infections. This is caused by several drawbacks that come with AMPs such as limited proteolytic stability and low selectivity against human cells. In this work, we screened a small library of rationally designed new peptides based on the cell-penetrating peptide sC18* toward their antimicrobial activity.
View Article and Find Full Text PDFControlling Excited State Localization in Bichromophoric Photosensitizers via the Bridging Group.
Inorg Chem
March 2024
Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
A series of photosensitizers comprised of both an inorganic and an organic chromophore are investigated in a joint synthetic, spectroscopic, and theoretical study. This bichromophoric design strategy provides a means by which to significantly increase the excited state lifetime by isolating the excited state away from the metal center following intersystem crossing. A variable bridging group is incorporated between the donor and acceptor units of the organic chromophore, and its influence on the excited state properties is explored.
View Article and Find Full Text PDFBypassing the Need for Cell Permeabilization: Nanobody CDR3 Peptide Improves Binding on Living Bacteria.
Bioconjug Chem
July 2023
Microbial Resistance and Drug Discovery, VIB-VUB Center for Structural Biology, VIB, Flanders Institute for Biotechnology, 1050 Brussels, Belgium.
Membrane interaction constitutes to be an essential parameter in the mode of action of entities such as proteins, as well as cell-penetrating and antimicrobial peptides, resulting in noninvasive or lytic activities depending on the membrane compositions and interactions. Recently, a nanobody able to interact with the top priority, multidrug-resistant bacterial pathogen was discovered, although binding took place with fixed cells only. To potentially overcome this limitation, linear peptides corresponding to the complementarity-determining regions (CDR) were synthesized and fluorescently labeled.
View Article and Find Full Text PDFPhage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA.
Eur J Med Chem
March 2022
Department of Drug Design and Optimization (DDOP), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123, Saarbrücken, Germany; Department of Pharmacy, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany. Electronic address:
Small macrocyclic peptides are promising candidates for new anti-infective drugs. To date, such peptides have been poorly studied in the context of anti-virulence targets. Using phage display and a self-designed peptide library, we identified a cyclic heptapeptide that can bind the carbon storage regulator A (CsrA) from Yersinia pseudotuberculosis and displace bound RNA.
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