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Are benzo[a]pyrene-DNA adducts an accurate biomarker of long-term in utero exposure to smoking? | LitMetric

Are benzo[a]pyrene-DNA adducts an accurate biomarker of long-term in utero exposure to smoking?

Ther Drug Monit

PériTox-INERIS (EA4285-UMI01), Laboratory of Toxicology, Jules Verne University of Picardy, Neonatal and Pediatric Intensive Care Unit, Amiens University Medical Center, Amiens, France.

Published: June 2011

AI Article Synopsis

Article Abstract

Background: Maternal smoking during pregnancy is associated with adverse perinatal outcomes. In view of concerns about underreporting, benzo[a]pyrene (B[a]P)-DNA adducts could be used to provide information about long-term in utero exposure to smoking but have not previously been used with samples from neonates. This study aimed to verify whether B[a]P-DNA adducts could accurately assess tobacco smoke exposure during fetal life. The objectives were to correlate B[a]P-DNA adduct levels with active maternal and passive smoking and to determine the sensitivity and specificity of smoking and nonsmoking status by comparing neonatal B[a]P-DNA adduct levels with those of maternal self-reports.

Materials And Methods: B[a]P-DNA adducts in neonatal buccal cell samples were determined by a competitive immunoassay. Three groups of neonates were constituted according to maternal self-reported smoking status during pregnancy: nonsmokers (n=25; control group), <10 cigarettes per day (n=18; S- group), or >10 cigarettes per day (n=21; S+ group).

Results: The mean B[a]P-DNA adduct level rose significantly when comparing the controls with the S- and S+ groups. Maternal active smoking had the strongest effect on B[a]P-DNA adduct levels in neonates. A cross analysis between B[a]P-DNA adduct levels and maternal self-reported levels revealed high sensitivity and specificity.

Conclusions: This preliminary study suggests that B[a]P-DNA adducts are reliable biomarkers for the screening of long-term in utero exposure to smoking and are accurate when compared with maternal self-reported levels of active smoking. Detection of B[a]P-DNA adducts in neonates could provide a useful, noninvasive tool in clinical risk assessment studies but would benefit from further confirmation with another validated biomarker.

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Source
http://dx.doi.org/10.1097/FTD.0b013e31821bb660DOI Listing

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