Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1056/NEJMc1007241 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8T cells function in the HCC microenvironment.
Signal Transduct Target Ther
January 2025
Department of Hepatobiliary Surgery, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
CD8T cells within the tumor microenvironment (TME) are often functionally impaired, which limits their ability to mount effective anti-tumor responses. However, the molecular mechanisms behind this dysfunction remain incompletely understood. Here, we identified valosin-containing protein (VCP) as a key regulator of CD8T cells suppression in hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFThymol inhibits ergosterol biosynthesis in Nakaseomyces glabratus, but differently from azole antifungals.
J Mycol Med
December 2024
Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
Introduction: Nakaseomyces glabratus is considered a high priority of attention according to WHO, and also is an important yeast species due to its high rate of intrinsic/acquired resistance against fluconazole. This study aimed at the possible mechanisms of action of thymol, as the promising new antifungal agent, in N. glabratus.
View Article and Find Full Text PDFMechanisms of regulated cell death during plant infection by the rice blast fungus Magnaporthe oryzae.
Cell Death Differ
January 2025
The Sainsbury Laboratory, University of East Anglia, Norwich, UK.
Fungi are the most important group of plant pathogens, responsible for many of the world's most devastating crop diseases. One of the reasons they are such successful pathogens is because several fungi have evolved the capacity to breach the tough outer cuticle of plants using specialized infection structures called appressoria. This is exemplified by the filamentous ascomycete fungus Magnaporthe oryzae, causal agent of rice blast, one of the most serious diseases affecting rice cultivation globally.
View Article and Find Full Text PDFSerum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism.
Neurobiol Dis
January 2025
Department of Neurology, the University of Texas McGovern Medical School at Houston, TX, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX, USA; UTHealth Consortium on Aging, the University of Texas McGovern Medical School, Houston, TX, USA. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is more prevalent in women than in men, with factors beyond longevity, like metabolic changes, influencing this increased risk.
- A study conducted metabolomic profiling of blood samples from male and female patients with mild cognitive impairment (MCI), revealing significant metabolic differences related to sex, particularly in lipid and peptide energy metabolism pathways.
- The research identified specific metabolites unique to each sex, such as higher levels of 1-palmitoleoyl glycerol in females, suggesting these could be potential biomarkers to enhance our understanding of MCI and AD prevention strategies.
Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism.
bioRxiv
November 2024
Department of Neurology, the University of Texas McGovern Medical School at Houston, TX, USA.
Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways have been implicated in AD progression, but studies to date examined targeted pathways, leaving many metabolites unmeasured.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!