AI Article Synopsis
- Researchers studied how NO donors like sodium nitroprusside affect human platelets and red blood cells.
- They found that NO donors cause platelets to disaggregate and alter their elasticity, as seen through atomic force microscopy.
- Additionally, they discovered that NO donors delay hemolysis in red blood cells and lower their elasticity modulus, suggesting that NO donors play a role in regulating cell properties.
Article Abstract
The effect of NO donors (sodium nitroprusside, S-nitrosoglutathione, dinitrosyl-iron complexes) on the functional and mechanical properties of human platelets and red blood cells has been investigated. It has been established by atomic force microscopy that NO donor-induced platelet disaggregation is accompanied by changes in the elastic properties of cells. It has been shown that, in the presence of NO donors, the detergent-induced hemolysis of red blood cells is delayed, and the elasticity modulus of these cells decreases. The results obtained indicate that NO donors regulate the structural and functional properties of platelets and red blood cells.
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