Cell death has gained considerable interest during the last few years since, along with mitosis, it contributes to the determination of normal or neoplastic state of tissues. Cell death can occur in two ways: necrosis Or 'accidental' death and apoptosis or 'programmed' death. The focus on apoptosis is very recent. Like cell division it involves an interesting set of genetic regulations. The apoptosis-preventing bcl-2 gene, therefore emerges as a key-gene at the crossroad of cell death and cell proliferation: the two facets of the oncogenesis-governing equation.
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| http://dx.doi.org/10.3892/ijo.9.3.563 | DOI Listing |
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