AI Article Synopsis
- The Mps One binder (MOB) protein family is conserved across eukaryotes, playing essential roles in mitotic exit and cell morphogenesis, initially identified in yeast.
- Research in fruit flies highlighted that dMOB1/MATS is crucial in Hippo signaling, where its loss leads to increased cell growth and decreased cell death, indicating its role as a tumor suppressor.
- Recent studies on hMOB1 in mammalian cells reveal its regulation of NDR/LATS kinases, with hMOB2 acting as a counterbalance, emphasizing their importance in various biological functions like apoptosis, mitosis, and cell proliferation.
Article Abstract
The family of Mps One binder (MOB) co-activator proteins is highly conserved from yeast to man. At least two different MOB proteins have been identified in every eukaryote analysed to date. Initially, yeast genetics revealed essential roles for Mob1p and Mob2p in the regulation of mitotic exit and cell morphogenesis. Studies in flies then showed that dMOB1/MATS is a core component of Hippo signalling. Loss of dMOB1 resulted in increased cell proliferation and decreased cell death, suggesting that MOB1 acts as tumour suppressor protein. Recent work focused primarily on mammalian cells has shown how hMOB1 can regulate NDR/LATS kinases, a function that can to be counteracted by hMOB2. Here we summarise and discuss our current knowledge of this emerging protein family, with emphasis on subcellular localisation, protein-protein interactions and biological functions in apoptosis, mitosis, morphogenesis, cell proliferation and centrosome duplication.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398134 | PMC |
| http://dx.doi.org/10.1016/j.cellsig.2011.04.007 | DOI Listing |
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