AI Article Synopsis
- The study utilized a specialized imaging technique combining steady-state free precession and compressed sensing to enhance lung imaging using hyperpolarized (129) Xe in mice.
- Fast imaging allowed for improved temporal resolution, capturing clear lung images at different breathing phases.
- The findings revealed that mice with elastase-induced emphysema exhibited abnormal patterns in both ventilation and gas exchange compared to healthy mice.
Article Abstract
In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized (129) Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, (129) Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice.
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| http://dx.doi.org/10.1002/nbm.1697 | DOI Listing |
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