Orthopedic wear particles activate a number of intracellular signaling pathways associated with inflammation in macrophages and we have previously shown that the phosphoinositol-3-kinase (PI3K)/Akt pathway is one of the signal transduction pathways that mediates the in vitro activation of macrophages by orthopedic wear particles. Since PI3Kγ is primarily responsible for PI3K activity during inflammation, we hypothesized that PI3Kγ mediates particle-induced osteolysis in vivo. Our results do not strongly support the hypothesis that PI3Kγ regulates the overall amount of particle-induced osteolysis in the murine calvarial model. However, our results strongly support the conclusion that variability in the amount of particle-induced osteolysis between individual mice is reduced in the PI3Kγ(-/-) mice. These results suggest that PI3Kγ contributes to osteolysis to different degrees in individual mice and that the mice, and patients, that are most susceptible to osteolysis may be so, in part, due to an increased contribution from PI3Kγ.
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http://dx.doi.org/10.1002/jor.21440 | DOI Listing |
Macromol Rapid Commun
December 2024
Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, St. Gallen, 9014, Switzerland.
Facemask materials have been under constant development to optimize filtration performance, wear comfort, and general resilience to chemical and mechanical stress. While single-use polypropylene meltblown membranes are the established go-to material for high-performing mask filters, they are neither sustainable nor particularly resistant to sterilization methods. Herein an in-depth analysis is provided of the sterilization efficiency, filtration efficiency, and breathing resistance of selected aerosol filters commonly implemented in facemasks, with a particular focus on the benefits of nanofibrous filters.
View Article and Find Full Text PDFSci Rep
December 2024
The Ministry of Education Key Laboratory of High Efficiency Mining and Safety for Metal Mines & School of Civil and Resources Engineering, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China.
Coarse particles in filling slurry are the primary factor causing wear in filling elbow pipes, and the wear mechanism of these particles on the pipes is influenced by various factors. To study the erosion and wear mechanism of elbow pipes caused by coarse particles, the motion state of coarse particles under different curvature radii, coarse particle gradations, and pipe diameters was investigated using a simulation method based on the coupling of Fluent and EDEM software, grounded in theories of fluid mechanics, rheology, and solid-liquid two-phase flow. The study explored the impact patterns and locations of wear induced by coarse particles on filling elbow pipes.
View Article and Find Full Text PDFDeveloping novel materials is an essential requirement in the engineering field. This study investigates the effects of incorporating wood dust particles on the mechanical and erosive wear properties of Luffa acutangula fiber (LAF)-reinforced phenol-formaldehyde composites, fabricated using the hand layup method with a constant 20% fiber content and varying wood dust particle contents of 0%, 10%, 20%, and 30%. Using the Taguchi method, the study identifies the optimal combination for minimizing erosive wear - 20% wood dust content, 45 m/s impact velocity, 60° impingement angle, 600 μm erodent size, and 60 mm standoff distance-achieving a minimum erosion rate of 189.
View Article and Find Full Text PDFWaste Manag Res
December 2024
Chair of Waste Processing Technology and Waste Management, Department of Environmental and Energy Process Engineering, Montanuniversitaet Leoben, Leoben, Austria.
This article uses model materials to introduce a controlled, location- and manufacturer-independent internationally accepted method for assessing shredding machines based on large-scale tests. Furthermore, a better understanding of the comminution behaviour of shredders with fixed settings (gap width, shaft speed, cutting tool geometry) is in the focus of the present investigation and assessed, using the statistical analyses for particle size distribution in certain screen sections. Conclusions have been drawn on the comminution behaviour in general and the material-material interactions of different fractions in the grinding chamber of the shredder by showing significant differences in the pure fraction's comminution behaviour against the mixture's comminution behaviour.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
Department of Chemistry, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Developing a durable multifunctional superhydrophobic coating on polymeric films that can be industrially scalable is a challenge in the field of surface engineering. This article presents a novel method for a scalable technology using a simple single-step fabrication of a superhydrophobic coating on polymeric films that exhibits excellent water-repelling and UV-blocking properties, along with impressive wear resistance and chemical robustness. A mixture of titanium precursors, tetraethylorthosilicate (TEOS), hydrophobic silanes and silica nano/micro-particles is polymerized directly on a corona-treated polymeric film which reacts with the surface via siloxane chemistry.
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