Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125944 | PMC |
| http://dx.doi.org/10.1007/s12275-011-0396-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Mast Cell Activation on Neurodegeneration: A Potential Role for Gut-Brain Axis and Infection.
Neurol Int
December 2024
Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Background: The innate immune response aims to prevent pathogens from entering the organism and/or to facilitate pathogen clearance. Innate immune cells, such as macrophages, mast cells (MCs), natural killer cells and neutrophils, bear pattern recognition receptors and are thus able to recognize common molecular patterns, such as pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs), the later occurring in the context of neuroinflammation. An inflammatory component in the pathology of otherwise "primary cerebrovascular and neurodegenerative" disease has recently been recognized and targeted as a means of therapeutic intervention.
View Article and Find Full Text PDF: Routes of Infection, Antimicrobial Resistance, and Alternative Therapies as a Means to Develop Infection Control.
Diseases
December 2024
Department of Radiology, King Fahd Armed Forces Hospital, Jeddah 23311, Saudi Arabia.
() is a Gram-negative, spiral-shaped bacterium that colonizes the gastric epithelium and is associated with a range of gastrointestinal disorders, exhibiting a global prevalence of approximately 50%. Despite the availability of treatment options, frequently reemerges and demonstrates increasing antibiotic resistance, which diminishes the efficacy of conventional therapies. Consequently, it is imperative to explore non-antibiotic treatment alternatives to mitigate the inappropriate use of antibiotics.
View Article and Find Full Text PDFouter membrane vesicles and infected cell exosomes: new players in host immune modulation and pathogenesis.
Front Immunol
December 2024
Department of Clinical Laboratory, The First People's Hospital of Kunshan, Kunshan, Jiangsu, China.
Outer membrane vesicles (OMVs) and exosomes are essential mediators of host-pathogen interactions. Elucidating their mechanisms of action offers valuable insights into diagnosing and treating infectious diseases and cancers. However, the specific interactions of () with host cells via OMVs and exosomes in modulating host immune responses have not been thoroughly investigated.
View Article and Find Full Text PDFAsia-Pacific Survey on the Management of Helicobacter pylori Infection.
J Gastroenterol Hepatol
December 2024
Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Background And Aim: Gastric cancer (GC)-related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, and the importance of primary and secondary prevention of GC has been well recognized. We aimed to investigate the extent of overall agreement among clinicians in the Asia-Pacific region regarding the management of H. pylori infection.
View Article and Find Full Text PDFPathogenicity and virulence of : A paradigm of chronic infection.
Virulence
December 2025
The Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Infection with is one of the most common infections of mankind. Infection typically occurs in childhood and persists for the lifetime of the host unless eradicated with antimicrobials. The organism colonizes the stomach and causes gastritis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!