Membership in many natural categories is considered all-or-none, while membership in most artifact categories is found to be graded. We introduce an alternative for the prevailing view that this domain difference in categorization results from representational differences. The context variety account posits that an item's gradedness reflects the variety of contexts it appears in. Items that feature in a variety of contexts are assumed to be more likely to elicit a graded categorization response, since the suggested target category only provides one of many solutions to the question of the item's identity. We review earlier work that suggested a domain difference in context variety, with artifactual items appearing in a greater variety of contexts than natural ones. The context variety domain difference is established in two separate experiments but is shown not to explain the domain difference in categorization. A selection of artifactual and natural items, for which the domain difference in context variety is reversed, is presented for categorization in a third experiment. This selection, too, fails to provide evidence for the context variety account of categorization differences. The domain difference in categorization is shown to be robust against this manipulation. Context variety appears to have no bearing on categorization, so the context variety account is not a sustainable alternative to accounts that posit representational differences between natural and artifact categories.
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http://dx.doi.org/10.3758/s13421-011-0102-3 | DOI Listing |
Int J Pharm
January 2025
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:
The rising incidence of skin disorders has necessitated the exploration of innovative therapeutic modalities that harness the beneficial properties of natural compounds. Phytoconstituents, renowned for their diverse pharmacological attributes, present considerable promise in the management of various dermatological conditions. This review delineates the integration of phytoconstituents into ethosomal formulations, which are advanced lipid-based carriers specifically designed to enhance transdermal delivery.
View Article and Find Full Text PDFPlant Dis
January 2025
The University of Melbourne, Faculty of Science, School of Agriculture, Food and Ecosystem Sciences, Parkville, Victoria, Australia;
In Australia, pyrethrum (Tanacetum cinerariifolium) cultivation provides a significant portion of the global supply of natural insecticidal pyrethrins. However, crown and root rots, along with stunted plant growth and plant loss during winter, are significant issues affecting certain sites. Several isolates of the Fusarium oxysporum species complex (FOSC) have been identified as causal agents of crown and root rot in pyrethrum, highlighting these as key pathogens contributing to this decline.
View Article and Find Full Text PDFMol Cancer Ther
January 2025
Tango Therapeutics (United States), Boston, United States.
Synthetic lethality approaches in BRCA1/2-mutated cancers have focused on poly(ADP-ribose) polymerase (PARP) inhibitors, which are subject to high rates of innate or acquired resistance in patients. Here, we used CRISPR/Cas9-based screening to identify DNA Ligase I (LIG1) as a novel target for synthetic lethality in BRCA1-mutated cancers. Publicly available data supported LIG1 hyperdependence of BRCA1-mutant cells across a variety of breast and ovarian cancer cell lines.
View Article and Find Full Text PDFWorld J Clin Oncol
January 2025
Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou 416000, Hunan Province, China.
Background: Extramedullary plasmacytoma (EMP) represents one of the rarer forms of plasma cell malignancies, capable of impacting a variety of tissues and organs throughout the body. The majority of EMP cases are predominantly found in the head and neck region, especially within the laryngopharynx, as well as in the gastrointestinal tract. While there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature, it is important to note that EMP specifically affecting the uvula is exceedingly uncommon.
View Article and Find Full Text PDFStat Med
February 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Introduction: Risk prediction models are increasingly used in healthcare to aid in clinical decision-making. In most clinical contexts, model calibration (i.e.
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