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Wolbachia-Based Approaches to Controlling Mosquito-Borne Viral Threats: Innovations, AI Integration, and Future Directions in the Context of Climate Change.
Viruses
November 2024
Department of Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy.
Wolbachia-based mosquito control strategies have gained significant attention as a sustainable approach to reduce the transmission of vector-borne diseases such as dengue, Zika, and chikungunya. These endosymbiotic bacteria can limit the ability of mosquitoes to transmit pathogens, offering a promising alternative to traditional chemical-based interventions. With the growing impact of climate change on mosquito population dynamics and disease transmission, Wolbachia interventions represent an adaptable and resilient strategy for mitigating the public health burden of vector-borne diseases.
View Article and Find Full Text PDFVaccine Strategies Against RNA Viruses: Current Advances and Future Directions.
Vaccines (Basel)
November 2024
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
The development of vaccines against RNA viruses has undergone a rapid evolution in recent years, particularly driven by the COVID-19 pandemic. This review examines the key roles that RNA viruses, with their high mutation rates and zoonotic potential, play in fostering vaccine innovation. We also discuss both traditional and modern vaccine platforms and the impact of new technologies, such as artificial intelligence, on optimizing immunization strategies.
View Article and Find Full Text PDFMast Cells and Basophils in Major Viral Diseases: What Are the Correlations with SARS-CoV-2, Influenza A Viruses, HIV, and Dengue?
Cells
December 2024
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
The SARS-CoV-2 pandemic has significantly impacted global health and has led the population and the scientific community to live in fear of a future pandemic. Based on viral infectious diseases, innate immunity cells such as mast cells and basophils play a fundamental role in the pathogenesis of viral diseases. Understanding these mechanisms could be essential to better study practical therapeutic approaches not only to COVID-19 but also to other viral infections widely spread worldwide, such as influenza A, HIV, and dengue.
View Article and Find Full Text PDFElevated developmental temperatures below the lethal limit reduce Aedes aegypti fertility.
J Exp Biol
January 2025
School of BioSciences, Bio21 Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
Article Synopsis
- Aedes aegypti mosquitoes are key carriers of dengue, and factors like urbanization, climate change, and trade are affecting their populations.
- Higher temperatures have been shown to impact insect mortality and fertility, with this study focusing on how heat influences the fertility of Ae. aegyti across different generations.
- Results indicated that while mosquitoes can acclimate to heat, their fertility declines with increasing temperatures, affecting both male and female mosquitoes’ ability to reproduce and produce viable offspring, which could impact their populations in warmer climates.
Unlocking Success: Determining Predictors of High-Performance among COMBI Community Health Volunteers in Kuala Lumpur and Putrajaya.
Iran J Public Health
December 2024
Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Article Synopsis
- Community Health Volunteers (CHVs) play a vital role in public health, particularly in dengue prevention through the COMBI approach, with their performance being essential for program evaluation.
- A study in 2023 surveyed 285 CHVs in Kuala Lumpur and Putrajaya to assess performance levels and identify factors influencing high performance, using questionnaires and statistical tests.
- Results showed that 59.3% of CHVs performed at a high level, with key predictors including the adequacy of training, supervision by medical personnel, and high levels of motivation and job satisfaction, all of which could inform strategies for improving community healthcare delivery.
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