AI Article Synopsis
- The study aimed to create a model of traumatic ulcers in the rat cheek mucosa to aid future research on alternative therapies.
- A total of 60 male rats had their cheek mucosa ulcerated through abrasion and were monitored for 10 days, with significant weight loss initially and gradual healing of the ulcers.
- The results indicate that this model is a practical and effective method for studying ulcer healing and potential treatments.
Article Abstract
Purpose: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies.
Methods: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases.
Results: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day.
Conclusion: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.
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| http://dx.doi.org/10.1590/s0102-86502011000300012 | DOI Listing |
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