AI Article Synopsis
- Recent studies show a link between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) due to similarities in how β-cells and neurons function, especially concerning the secretion of specific molecules.
- Both conditions exhibit age-related changes in proteins, like hyperphosphorylated tau in AD and alterations in β-cells in T2DM, which may lead to increased cell death.
- Understanding these age-related protein modifications could inspire new treatment strategies to lower the rates of T2DM and AD.
Article Abstract
Frequent concomitant manifestation of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has been recently demonstrated by epidemiological studies. This might be due to functional similarities between β-cells and neurons, such as secretion on demand of highly specific molecules in a tightly controlled fashion. An additional similarity represents the age-related alteration of hyperphosphorylated tau in AD patients. Similarly, alterations have been identified in β-cells of T2DM patients. The islet amyloid polypeptide has been associated with β-cell apoptosis. As a consequence of increasing age, the accumulation of highly modified proteins together with decreased regenerative potential might lead to increasing rates of apoptosis. Moreover, reduction of β-cell replication capabilities results in reduction of β-cell mass in mammals, simultaneously with impaired glucose tolerance. The new challenge is to learn much more about age-related protein modifications. This can lead to new treatment strategies for reducing the incidence of T2DM and AD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083907 | PMC |
| http://dx.doi.org/10.4239/wjd.v2.i4.49 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!