Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC50 values in the range 0.7-9.7 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np200140j | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis.
Mol Med Rep
October 2015
Department of General Surgery, Port Hospital of Tianjin, Tianjin 300456, P.R. China.
Ponicidin is a diterpenoid extracted from the Chinese herb Isodon adenolomus, which has been reported as a therapeutic cytotoxic drug that may be used to treat various types of human cancer. The present study aimed to determine the antitumor effects of ponicidin, and to investigate its underlying mechanisms in colorectal cancer. The HT29 colorectal cancer cell line was used to detect the cytotoxicity of various doses of ponicidin.
View Article and Find Full Text PDFNeoadenoloside A, a highly functionalized diterpene C-glycoside, from Isodon adenolomus.
Chem Commun (Camb)
August 2012
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
Neoadenoloside A (1), an unprecedented diterpene C-glycoside with a unique C(26) framework, along with lasiokaurin (3) were isolated from the leaves of Isodon adenolomus. The absolute configuration of 2, a derivative of 1, was determined by spectroscopic methods and single-crystal X-ray diffraction analysis.
View Article and Find Full Text PDFStructure and cytotoxicity of diterpenoids from Isodon adenolomus.
J Nat Prod
May 2011
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!