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Targeting ultra-processed foods for prevention of type 2 diabetes: state of the evidence and future directions.
Diabetologia
January 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
The incidence of type 2 diabetes has risen globally, in parallel with the obesity epidemic and environments promoting a sedentary lifestyle and low-quality diet. There has been scrutiny of ultra-processed foods (UPFs) as a driver of type 2 diabetes, underscored by their increasing availability and intake worldwide, across countries of all incomes. This narrative review addresses the accumulated evidence from investigations of the trends in UPF consumption and the relationship with type 2 diabetes incidence.
View Article and Find Full Text PDFBackground: Poverty is considered one of the social determinants of health (i.e., a range of social and environmental conditions that affect health and well-being) because of its association with significant health problems.
View Article and Find Full Text PDFEnhancing Missense Variant Pathogenicity Prediction with MissenseNet: Integrating Structural Insights and ShuffleNet-Based Deep Learning Techniques.
Biomolecules
September 2024
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
The classification of missense variant pathogenicity continues to pose significant challenges in human genetics, necessitating precise predictions of functional impacts for effective disease diagnosis and personalized treatment strategies. Traditional methods, often compromised by suboptimal feature selection and limited generalizability, are outpaced by the enhanced classification model, MissenseNet (Missense Classification Network). This model, advancing beyond standard predictive features, incorporates structural insights from AlphaFold2 protein predictions, thus optimizing structural data utilization.
View Article and Find Full Text PDFAdvances in breeding phenology outpace latitudinal and elevational shifts for North American birds tracking temperature.
Nat Ecol Evol
November 2024
Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.
Terrestrial species can respond to a warming climate in multiple ways, including shifting in space (via latitude or elevation) and time (via phenology). Evidence for such shifts is often assessed independent of other temperature-tracking mechanisms; critically, no study has compared shifts across all three spatiotemporal dimensions. Here we used two continental-scale monitoring databases to estimate trends in the breeding latitude (311 species), elevation (251 species) and phenology (111 species) of North American landbirds over 27 years, with a shared pool of 102 species.
View Article and Find Full Text PDFPredicting the Collapse of Pain Medicine Using the Economic Recession of 2008 as a Comparator: Lessons Remain Unlearned.
J Pain Res
July 2024
Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY, USA.
The last decade has seen a boom in pain medicine, basic science and interventional pain management. Concomitantly, there is a need to educate trainees, young attendings, and seasoned attendings on these innovations. There has been a growth in the number of societies that represent pain medicine physicians, each with its own philosophy and guiding principles.
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