Introduction: This study investigated the outcomes and identified influencing factors of intensive integrated intervention over 2 years in Chinese patients with impaired glucose regulation (IGR).
Methods: Adults in Beijing, China, were screened for IGR using the 75 g oral glucose tolerance test. Participants with IGR received lifestyle and health education; those who still had IGR after 1 year were randomly assigned to either a routine care group or to an intensive integrated intervention group.
Results: Of 2344 adults screened, 463 had IGR. Of these, 210 adults had IGR after 1 year and were therefore recruited and randomized to an intensive integrated intervention group (n=106) or a control group (n=104). The percentage of patients who reached the set targets of plasma glucose, blood pressure, body mass index, or triglycerides was significantly higher in the intensive integrated intervention group. None of the patients within the intensive integrated intervention group progressed to diabetes, whereas eight (9.3%) cases of the control group developed type 2 diabetes mellitus (T2DM). Logistic regression analysis showed that both an increase in waist circumference and systolic blood pressure (SBP) were positively correlated with the development of T2DM, whereas improvement in islet beta cell function was negatively correlated with the development of T2DM.
Conclusions: Intensive integrated intervention may significantly decrease the conversion rate of IGR to T2DM, and increase the conversion ratio to normal glucose tolerance. The increase of waist circumference or SBP and the deterioration of islet beta cell function may be important risk factors for progression from prediabetes to diabetes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12325-011-0022-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of adjuvant hyperbaric oxygen therapy and real-time fluorescent imaging on deep sternal wound infection: a retrospective study.
J Wound Care
January 2025
Division of Plastic Surgery, Integrated Burn & Wound Care Center, Department of Surgery, Shuang-Ho Hospital, New Taipei City, Taiwan.
Objective: Deep sternal wound infection (DSWI) is a rare but devastating complication that is estimated to occur in 1-2% of patients after median sternotomy. Current standard of care (SoC) comprises antibiotics, debridement and negative pressure wound therapy (NPWT). Hyperbaric oxygen therapy (HBOT) appears to be an effective adjuvant therapy for osteomyelitis.
View Article and Find Full Text PDFIntegrative molecular and physiological insights into the phytotoxic impact of liquid crystal monomer exposure and the protective strategy in plants.
Plant Biotechnol J
January 2025
Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees, Ministry of Education, Central South University of Forestry and Technology, Changsha, China.
Liquid crystal monomers (LCMs), the integral components in the manufacture of digital displays, have engendered environmental concerns due to extensive utilization and intensive emission. Despite their prevalence and ecotoxicity, the LCM impacts on plant growth and agricultural yield remain inadequately understood. In this study, we investigated the specific response mechanisms of tobacco, a pivotal agricultural crop and model plant, to four representative LCMs (2OdF3B, 5CB, 4PiMeOP, 2BzoCP) through integrative molecular and physiological approaches.
View Article and Find Full Text PDFTendon Anomaly Identification in Prestressed Concrete Beams Based on an Advanced Monitoring MEMS and Data-Driven Detection of Structural Damage.
Sensors (Basel)
January 2025
Department of Structures for Engineering and Architecture, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy.
The growing importance of state assessments in civil engineering has led to intensive research into the development of damage identification methods based on vibrations. Natural frequencies and modal shapes have garnered great interest because modal parameters are invariant of structure. Moreover, thanks to the global nature of modal parameters, their variations are not limited to the location of the damage.
View Article and Find Full Text PDFVariable-Parameter Impedance Control of Manipulator Based on RBFNN and Gradient Descent.
Sensors (Basel)
December 2024
Xi'an Institute of Optics and Precision Mechanics of CAS, Xi'an 710119, China.
During the interaction process of a manipulator executing a grasping task, to ensure no damage to the object, accurate force and position control of the manipulator's end-effector must be concurrently implemented. To address the computationally intensive nature of current hybrid force/position control methods, a variable-parameter impedance control method for manipulators, utilizing a gradient descent method and Radial Basis Function Neural Network (RBFNN), is proposed. This method employs a position-based impedance control structure that integrates iterative learning control principles with a gradient descent method to dynamically adjust impedance parameters.
View Article and Find Full Text PDFDoes the Administration of Intravenous Fluid Matter in the Context of the Incidence of Postoperative Complications After Radical Cystectomy?
Cancers (Basel)
December 2024
Department of Urology and Andrology, Collegium Medicum, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.
Intravenous fluid management is integral to perioperative care, particularly under enhanced recovery after surgery (ERAS) protocols. In radical cystectomy (RC), which carries high risks of complications and mortality, optimizing fluid management poses a significant challenge due to the absence of definitive guidelines. the purpose of this study was to investigate the effects of intravenous fluid administration on postoperative complications in patients undergoing RC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!