Objectives: To analyze the effect of blood collection and storage conditions on activity of α-galactosidase A, arylsulfatase B and α-glucosidase.
Design And Methods: Blood was collected in EDTA, heparin, or direct spotting on filter paper and stored at different temperatures (-20, 4, 25 and 37°C) and storage times (3, 10, 17 and 180 days). The influence of filter paper size was also assessed (3.0 and 1.2mm).
Results: No statistically significant difference was observed between the three collection methods. α-Glucosidase A activity significantly decreased after the 10th day, while arylsulfatase B activity only differed significantly after the 180th day, and α-galactosidase A activity remained constant throughout this storage time. Excellent correlation coefficients were observed for the two filter paper sizes used.
Conclusions: Both paper sizes may be employed. Filter paper specimens should be transported under refrigeration as soon as possible after blood collection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinbiochem.2011.03.138 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.
Database (Oxford)
January 2025
Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.
The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.
View Article and Find Full Text PDFIn the field of image processing, optical neural networks offer advantages such as high speed, high throughput, and low energy consumption. However, most existing coherent optical neural networks (CONN) rely on coherent light sources to establish transmission models. The use of laser inputs and electro-optic modulation devices at the front end of these neural networks diminishes their computational capability and energy efficiency, thereby limiting their practical applications in object detection tasks.
View Article and Find Full Text PDFOptical transceivers serve as the backbone of high-speed data transmission over optical fiber in communication systems and there is a constant challenge to keep cost and power consumption low while increasing data capacities. However, dispersion impairments introduced by the transmission of data over optical fiber, limit the baud rates and fiber reach. In this paper, we demonstrate a low loss, transmission-based grating device to compensate for dispersion up to 20 km by the concatenation of gratings where the operation occurs outside of the stopband in the region where transmissivity is high, and the normal dispersion magnitude is large.
View Article and Find Full Text PDFAn adaptive polarization controller (APC) is crucial in mitigating carrier fading in a self-homodyne coherent detection (SHCD) system. In this paper, we propose a simplified APC design based on the X-cut, Y-propagating lithium niobate platform. Meanwhile, the alpha-beta filter is used to control the designed APC.
View Article and Find Full Text PDFThis paper proposes an imaging technique to remove strong reflections from specular surfaces using polarization characteristics combined with light field imaging. Firstly, the correct strong reflection region is found by studying the reflected light characteristics, and the strong reflection region highlights are filtered out using Stokes parameters based on polarization information. Then, a system of microlens arrays with different transmittances was built for imaging, and the system was image-corrected to enable more information about the scene to be captured.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!