Several studies show that the findings of clinical trials are often not published in full, resulting in a biased presentation of results (publication bias). First, this paper discusses the ethical arguments in favour of complete transparency of biomedical research data. There are relevant deontological (like obligations towards study participants and research sponsors) and consequentialist (harm for patients and misallocation of scarce resources) ethical reasons for the full publication of all trial results, which cannot be overridden by counter arguments like freedom of research, data protection or the individual interests of researchers and manufacturers. The article therefore discusses (1) which strategies are appropriate to guarantee data transparency and (2) who bears responsibility for the implementation of these strategies. Finally, open questions and the need for further action will be discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.zefq.2011.03.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Migration of Health Workers and Its Impacts on the Nigerian Health Care Sector: Protocol for a Scoping Review.
JMIR Res Protoc
January 2025
Department of Medicine and Optometry, eHealth Institue, Linnaeus University, Kalmar, Sweden.
Background: Health worker migration from Nigeria poses significant challenges to the Nigerian health care sector and has far-reaching implications for health care systems globally. Understanding the factors driving migration, its effects on health care delivery, and potential policy interventions is critical for addressing this complex issue.
Objective: This study aims to comprehensively examine the factors encouraging the emigration of Nigerian health workers, map out the effects of health worker migration on the Nigerian health system, document the loss of investment in health training and education resulting from migration, identify relevant policy initiatives addressing migration, determine the effects of Nigerian health worker migration on destination countries, and identify the benefits and demerits to Nigeria of health worker migration.
Registered reports in psychology across scholarly citations and public dissemination: A comparative metaevaluation of more than a decade of practice.
Am Psychol
January 2025
Department of Applied Psychology, Chinese University of Hong Kong, Shenzhen.
After more than a decade of practice, registered reports (RRs) are widely adopted in psychology. However, the acceptance of RRs in terms of postpublication academic recognition and public dissemination, compared with nonregistered reports (non-RR), remained largely unexplored. This matched meta-evaluation identified and analyzed 119 pairs of original research articles (RR vs.
View Article and Find Full Text PDFReporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).
Br J Nutr
January 2025
Federal University of Health Sciences of Porto Alegre, Department of Nutrition, Postgraduate Program in Health Sciences, Porto Alegre, Brazil.
Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted.
View Article and Find Full Text PDFArthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry data from an international perspective.
Acta Orthop
January 2025
Emeritus Consultant Orthopaedic Surgeon, Wrightington Hospital; Bristol University, UK.
Background And Purpose: The amount of information publicly available from arthroplasty registries is large but could be used more effectively. This project aims to improve the knowledge concerning existing registries to facilitate access, transparency, harmonization, and reporting.
Methods: Within the International Society of Arthroplasty Registries (ISAR) we aimed at developing, testing, adopting, and making publicly available a short, standardized registry description with items considered relevant for stakeholders using a cross-sectional study survey.
AI integration into wavelength-based SPR biosensing: Advancements in spectroscopic analysis and detection.
Anal Chim Acta
March 2025
Artificial Intelligence Research Center, Chang Gung University, Taoyuan, 333323, Taiwan; Department of Artificial Intelligence, College of Intelligent Computing, Chang Gung University, Taoyuan, 333323, Taiwan. Electronic address:
Background: In recent years, employing deep learning methods in the biosensing area has significantly reduced data analysis time and enhanced data interpretation and prediction accuracy. In some SPR fields, research teams have further enhanced detection capabilities using deep learning techniques. However, the application of deep learning to spectroscopic surface plasmon resonance (SPR) biosensors has not been reported.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!