AI Article Synopsis
- The study examined tumor cellularities in 23 cases of infiltrating ductal carcinoma of the breast and looked at how they relate to various clinical and pathological features.
- The Cellularity Mean Index (CMI), which measures the percentage of tumor volume made up of invasive tumor cells, showed significant links to lymph node involvement (P = 0.03) and mitotic activity (P = 0.0002).
- The findings suggest that as tumor cellularity increases, so does the mitotic activity of the cells, indicating a potential relationship between these two factors in breast cancer progression.
Article Abstract
Tumor cellularities were observed in 23 consecutive cases of infiltrating ductal carcinoma of the breast and correlated with other morphometric, pathologic, and clinical features. The cellularity mean index (CMI), defined as the percentage of tumor volume occupied by invasive tumors cells, was found to correlate with lymph node involvement by tumor (P = 0.03) and the number of mitotic figures per ten high-power fields (P = 0.0002). The CMI also correlated with mitotic activity (P = 0.01) when the latter was expressed as the percentage of tumor cells actively in mitosis, thus correcting for differences in cellularity between individual tumors. The relationship between cellularity and mitotic activity is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ajcp/93.1.98 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Myeloid-derived suppressor cells (MDSCs) are expanded in cancer patients, have an intrinsic immunosuppressive function, and thus may play a role in resistance to immunotherapy. Ulceration of the melanoma primary is associated with more aggressive disease and is an independent prognostic factor for melanoma-specific survival. However, the underlying factors contributing to this more aggressive phenotype are not completely understood.
View Article and Find Full Text PDFCancers of the brain and central nervous system: global patterns and trends in incidence.
J Neurooncol
January 2025
Cancer Surveillance Branch, International Agency for Research On Cancer (IARC), 25 Avenue Tony Garnier, CS 90627, 69366 LYON CEDEX 07, Lyon, France.
Background: Global comparisons of the burden and impact of cancers of the brain and central nervous system (CNS) are critical for developing effective control strategies and generating etiological hypotheses to drive future research.
Methods: National incidence estimates were obtained from GLOBOCAN 2022, and recorded incidence data from the Cancer in Five Continents series, both developed and compiled by the International Agency for Research on Cancer. We examined the estimated age-standardized incidence rates in 185 countries, as well as time trends in recorded incidence in 35 countries, quantifying the direction and change in the magnitude of the rates using the estimated average percentage change (EAPC).
One-day dual-tracer examination in neuroendocrine neoplasms: a real advantage of low activity LAFOV PET imaging.
Eur J Nucl Med Mol Imaging
January 2025
Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Otfried-Mueller-Str. 14, 72076, Tuebingen, Germany.
Purpose: Somatostatin receptor (SSTR)-PET is crucial for effective treatment stratification of neuroendocrine neoplasms (NENs). In highly proliferating or poorly differentiated NENs, dual-tracer approaches using additional [F]FDG PET can effectively identify SSTR-negative disease, usually requiring separate imaging sessions. We evaluated the feasibility of a one-day dual-tracer imaging protocol with a low activity [F]FDG PET followed by an SSTR-PET using the recently introduced [F]SiFAlin-TATE tracer in a long axial field-of-view (LAFOV) PET/CT scanner and its implications in patient management.
View Article and Find Full Text PDFMedical management pathways for Cushing's disease in pituitary tumors centers of excellence (PTCOEs).
Pituitary
January 2025
Division of Endocrinology, Santiago de Compostela University and Ciber OBN, Santiago, Spain.
Purpose: A recent update of consensus guidelines for the management of Cushing's disease (CD) included indications for medical therapy. However, there is limited evidence regarding their implementation in clinical practice. This study aimed to evaluate current medical therapy approaches by expert pituitary centers through an audit conducted to validate the criteria of Pituitary Tumors Centers of Excellence (PTCOEs) and provide an initial standard of medical care for CD.
View Article and Find Full Text PDFDifferences in Inpatient Palliative Care Consultation During the Terminal Admission for Pediatric Neuro-Oncology Patients.
Am J Hosp Palliat Care
January 2025
Department of Pediatrics, University of Chicago, Comer Children's Hospital, Chicago, IL, USA.
Pediatric neuro-oncology patients have one of the highest mortality rates among all children with cancer. Our study examines the potential relationship between palliative care consultation and intensity of in-hospital care and determines if racial and ethnic differences are associated with palliative care consultations during their terminal admission. Retrospective observational study using the Pediatric Health Information System (PHIS) database with data from U.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!