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Extracellular matrix mimetic supramolecular hydrogels reinforced with covalent crosslinked mesoporous silica nanoparticles.
J Mater Chem B
December 2024
Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P. O. Box 616, 6200 MD Maastricht, The Netherlands.
Article Synopsis
- The extracellular matrix (ECM) is crucial for tissue regeneration, and researchers are interested in developing hydrogels that mimic its dynamic and fibrous structure for regenerative medicine.
- A new hybrid hydrogel network was created by combining supramolecular assemblies with covalent crosslinkers made from mesoporous silica nanoparticles (MSNs) and functionalized macromonomers, enhancing the mechanical properties.
- The resulting NBTA-MSN nanocomposites showed improved structural stability, elasticity, self-healing, injectability, and good cytocompatibility, along with the ability to serve as calcium and phosphate ion reservoirs, making them promising materials for various applications.
The Structural Dispersity of Oligoethylene Glycol-Containing Polymer Brushes Determines Their Interfacial Properties.
J Am Chem Soc
June 2024
Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Ought to their bioinert properties and facile synthesis, poly[(oligoethylene glycol)methacrylate]s (POEGMAs) have been raised as attractive alternatives to poly(ethylene glycols) (PEGs) in an array of (bio)material applications, especially when they are applied as polymer brush coatings. However, commercially available OEG-methacrylate (macro)monomers feature a broad distribution of OEG lengths, thus generating structurally polydisperse POEGMAs when polymerized through reversible deactivation radical polymerization. Here, we demonstrate that the interfacial physicochemical properties of POEGMA brushes are significantly affected by their structural dispersity, , the degree of heterogeneity in the length of side OEG segments.
View Article and Find Full Text PDFModifying the Backbone Chemistry of PEG-Based Bottlebrush Block Copolymers for the Formation of Long-Circulating Nanoparticles.
Adv Healthc Mater
September 2024
Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.
Nanoparticle physicochemical properties have received great attention in optimizing the performance of nanoparticles for biomedical applications. For example, surface functionalization with small molecules or linear hydrophilic polymers is commonly used to tune the interaction of nanoparticles with proteins and cells. However, it is challenging to control the location of functional groups within the shell for conventional nanoparticles.
View Article and Find Full Text PDFProlonged delivery of HIV-1 vaccine nanoparticles from hydrogels.
Int J Pharm
May 2024
Department of Pharmaceutical Technology, University of Regensburg, Universitaetsstrasse 31, 93040 Regensburg, Germany. Electronic address:
Immunization is a straightforward concept but remains for some pathogens like HIV-1 a challenge. Thus, new approaches towards increasing the efficacy of vaccines are required to turn the tide. There is increasing evidence that antigen exposure over several days to weeks induces a much stronger and more sustained immune response compared to traditional bolus injection, which usually leads to antigen elimination from the body within a couple of days.
View Article and Find Full Text PDFAn organometallic swap strategy for bottlebrush polymer-protein conjugate synthesis.
Chem Commun (Camb)
April 2024
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
Polymer-protein bioconjugation offers a powerful strategy to alter the physical properties of proteins, and various synthetic polymer compositions and architectures have been investigated for this purpose. Nevertheless, conjugation of molecular bottlebrush polymers (BPs) to proteins remains an unsolved challenge due to the large size of BPs and a general lack of methods to transform the chain ends of BPs into functional groups suitable for bioconjugation. Here, we present a strategy to address this challenge in the context of BPs prepared by "graft-through" ring-opening metathesis polymerization (ROMP), one of the most powerful methods for BP synthesis.
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