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| http://dx.doi.org/10.3201/eid1705.101824 | DOI Listing |
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Background: Kyasanur forest disease virus (KFDV) is a tick-borne flavivirus causing debilitating and potentially fatal disease in people in the Western Ghats region of India. The transmission cycle is complex, involving multiple vector and host species, but there are significant gaps in ecological knowledge. Empirical data on pathogen-vector-host interactions and incrimination have not been updated since the last century, despite significant local changes in land use and the expansion of KFD to new areas.
View Article and Find Full Text PDFA simple improved method for extracting DNA from ethanol-preserved hard ticks and its applications.
Infect Genet Evol
January 2025
Division of Vector Biology and Control, Indian Council of Medical Research - Vector Control Research Centre (ICMR-VCRC), Puducherry 605006, India. Electronic address:
Article Synopsis
- Hard tick exoskeletons make DNA extraction difficult, prompting researchers to test a modified method for extracting DNA from ethanol-preserved ticks for genetic studies.
- The new method was compared to three commercial kits and showed similar DNA concentration and purity across different life stages of ticks.
- The extracted DNA was used for PCR amplification of phylogenetic markers to analyze Amblyomma integrum, a potential disease vector, demonstrating a cost-effective approach that can aid genetic research in low-resource settings.
Alkhumra Hemorrhagic Fever Virus (AHFV): A Concise Overview.
Yale J Biol Med
December 2024
Multidisciplinary Research Unit (MRU), Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
Alkhumra fever is a viral disease caused by the Alkhumra hemorrhagic fever virus (AHFV). It belongs to family , genus . AHFV is primarily transmitted to humans through the bite of infected ticks, for example, .
View Article and Find Full Text PDFPurification and characterization of kyasanur forest disease virus EDIII domain of major envelope glycoprotein.
J Virol Methods
December 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee, Uttarakhand, India. Electronic address:
Current research efforts are underway to create novel approaches for the efficient diagnosis, monitoring, and mitigation of Kyasanur Forest Disease Virus (KFDV) infections. Flavivirus subunit-based vaccines based on envelope glycoprotein EDIII are now in preclinical and clinical research stages. Efficient purification and isolation methods for surface immunogenic viral antigens, including the recombinant envelope immunoglobulin-like domain III (rEDIII) protein, are crucial for the production and manufacturing of promising vaccine candidates that have been extensively assessed in previous literature.
View Article and Find Full Text PDFInsights into the virome of Hyalomma marginatum in the Danube Delta: a major vector of Crimean-Congo hemorrhagic fever virus in Eastern Europe.
Parasit Vectors
November 2024
Pathogen Discovery Laboratory, Institut Pasteur, Université Paris Cité, 75015, Paris, France.
Background: Ticks are significant vectors of pathogens, including viruses, bacteria, and protozoa. With approximately 900 tick species worldwide, many are expanding their geographical range due to changing socioeconomic and climate factors. The Danube Delta, one of Europe's largest wetlands, is an ecosystem that, despite its ecological importance, remains understudied concerning the risk of introducing new tick-borne viruses.
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